ArticleJournal of bacteriology2008
Dual promoters control expression of the Bacillus anthracis virulence factor AtxA.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Influence of the phosphoenolpyruvate:carbohydrate phosphotransferase system on toxin gene expression and virulence in Bacillus anthracis.Molecular microbiology · 2020Article
- Bacillus anthracis Virulence Regulator AtxA Binds Specifically to theJournal of bacteriology · 2019Article
- TheMicrobiology spectrum · 2019Review
- Exploitation of Bacillus subtilis as a robust workhorse for production of heterologous proteins and beyond.World journal of microbiology & biotechnology · 2018Review
- Article
- Experimental Validation of Bacillus anthracis A16R Proteogenomics.Scientific reports · 2015Article
- Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2 through an AtxA-dependent mechanism.BMC genomics · 2014Article
- Carbon dioxide-sensing in organisms and its implications for human disease.Cellular and molecular life sciences : CMLS · 2014Review
- SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02.Journal of industrial microbiology & biotechnology · 2014Article
- The two CcdA proteins of Bacillus anthracis differentially affect virulence gene expression and sporulation.Journal of bacteriology · 2013Article
- Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis.Journal of bacteriology · 2013Article
- cis-Acting elements that control expression of the master virulence regulatory gene atxA in Bacillus anthracis.Journal of bacteriology · 2012Article
- Glucose-dependent activation of Bacillus anthracis toxin gene expression and virulence requires the carbon catabolite protein CcpA.Journal of bacteriology · 2011Article
- The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence.Infection and immunity · 2009Article
- Two small c-type cytochromes affect virulence gene expression in Bacillus anthracis.Molecular microbiology · 2009Article
- A unique GTP-dependent sporulation sensor histidine kinase in Bacillus anthracis.Journal of bacteriology · 2009Article
- The bicarbonate transporter is essential for Bacillus anthracis lethality.PLoS pathogens · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The AtxA virulence regulator of Bacillus anthracis is required for toxin and capsule gene expression. AtxA is a phosphotransferase system regulatory domain-containing protein whose activity is regulated by phosphorylation/dephosphorylation of conserved histidine residues. Here we report that transcription of the atxA gene occurs from two independent promoters, P1 (previously described by Dai et al. [Z. Dai, J. C. Sirard, M. Mock, and T. M. Koehler, Mol. Microbiol. 16:1171-1181, 1995]) and P2, whose transcription start sites are separated by 650 bp. Both promoters have -10 and -35 consensus sequences compatible with recognition by sigma(A)-containing RNA polymerase, and neither promoter depends on the sporulation sigma factor SigH. The dual promoter activity and the extended untranslated mRNA suggest that as-yet-unknown regulatory mechanisms may act on this region to influence the level of AtxA in the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.