ArticleJournal of bacteriology2008
Isorenieratene biosynthesis in green sulfur bacteria requires the cooperative actions of two carotenoid cyclases.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Tandem-sgRNA Provides an Effective Reverse Genetic Approach for Suppression of Streptomyces Biosynthetic Gene Clusters and Secondary Metabolism.ACS synthetic biology · 2026Article
- Anoxygenic photosynthesis with emphasis on green sulfur bacteria and a perspective for hydrogen sulfide detoxification of anoxic environments.Frontiers in microbiology · 2024Review
- Genome features and secondary metabolite potential of the marine symbiont Streptomyces sp. RS2.Archives of microbiology · 2023Article
- Comparative genomic insights into habitat adaptation of coral-associatedFrontiers in microbiology · 2023Article
- Lipid biomarkers: molecular tools for illuminating the history of microbial life.Nature reviews. Microbiology · 2022Review
- Carotenoid biomarkers in Namibian shelf sediments: Anoxygenic photosynthesis during sulfide eruptions in the Benguela Upwelling System.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pathway engineering for high-yield production of lutein in Escherichia coli.Synthetic biology (Oxford, England) · 2021Article
- "Frontiers in microbiology · 2021Article
- Multiplicity of carotene patterns derives from competition between phytoene desaturase diversification and biological environments.Scientific reports · 2020Article
- Molecular and isotopic evidence reveals the end-Triassic carbon isotope excursion is not from massive exogenous light carbon.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Influence of the polar light cycle on seasonal dynamics of an Antarctic lake microbial community.Microbiome · 2020Article
- Niche expansion for phototrophic sulfur bacteria at the Proterozoic-Phanerozoic transition.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome Sequences of a Green-Colored Chlorobium phaeovibrioides Strain Containing Two Plasmids and a Closely Related Plasmid-Free Brown-Colored Strain.Microbiology resource announcements · 2020Article
- Genome Sequences of Green- and Brown-Colored Strains of Chlorobium phaeovibrioides with Gas Vesicles.Microbiology resource announcements · 2019Article
- Construction of a pathway to C50-ε-carotene.PloS one · 2019Article
- A paralog of a bacteriochlorophyll biosynthesis enzyme catalyzes the formation of 1,2-dihydrocarotenoids in green sulfur bacteria.The Journal of biological chemistry · 2018Article
- Synechocystis sp. PCC 6803 CruA (sll0147) encodes lycopene cyclase and requires bound chlorophyll a for activity.Photosynthesis research · 2017Article
- BciD Is a Radical S-Adenosyl-l-methionine (SAM) Enzyme That Completes Bacteriochlorophyllide e Biosynthesis by Oxidizing a Methyl Group into a Formyl Group at C-7.The Journal of biological chemistry · 2017Article
- Speciation and ecological success in dimly lit waters: horizontal gene transfer in a green sulfur bacteria bloom unveiled by metagenomic assembly.The ISME journal · 2017Article
- Synthetic biology and metabolic engineering for marine carotenoids: new opportunities and future prospects.Marine drugs · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cyclization of lycopene to gamma- or beta-carotene is a major branch point in the biosynthesis of carotenoids in photosynthetic bacteria. Four families of carotenoid cyclases are known, and each family includes both mono- and dicyclases, which catalyze the formation of gamma- and beta-carotene, respectively. Green sulfur bacteria (GSB) synthesize aromatic carotenoids, of which the most commonly occurring types are the monocyclic chlorobactene and the dicyclic isorenieratene. Recently, the cruA gene, encoding a conserved hypothetical protein found in the genomes of all GSB and some cyanobacteria, was identified as a lycopene cyclase. Further genomic analyses have found that all available fully sequenced genomes of GSB encode an ortholog of cruA. Additionally, the genomes of all isorenieratene-producing species of GSB encode a cruA paralog, now named cruB. The cruA gene from the chlorobactene-producing GSB species Chlorobaculum tepidum and both cruA and cruB from the brown-colored, isorenieratene-producing GSB species Chlorobium phaeobacteroides strain DSM 266(T) were heterologously expressed in lycopene- and neurosporene-producing strains of Escherichia coli, and the cruB gene of Chlorobium clathratiforme strain DSM 5477(T) was also heterologously expressed in C. tepidum by inserting the gene at the bchU locus. The results show that CruA is probably a lycopene monocyclase in all GSB and that CruB is a gamma-carotene cyclase in isorenieratene-producing species. Consequently, the branch point for the synthesis of mono- and dicyclic carotenoids in GSB seems to be the modification of gamma-carotene, rather than the cyclization of lycopene as occurs in cyanobacteria.
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