ArticleBiophysical journal2008
Influence of liquid-layer thickness on pulmonary surfactant spreading and collapse.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
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- Surface tension effects on flow dynamics and alveolar mechanics in the acinar region of human lung.Heliyon · 2022Article
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- Simulation of nanoparticle transport and adsorption in a microfluidic lung-on-a-chip device.Biomicrofluidics · 2020Article
- The asbestos-carbon nanotube analogy: An update.Toxicology and applied pharmacology · 2018Review
- Design and development of a biorelevant simulated human lung fluid.Journal of drug delivery science and technology · 2018Article
- Differential Effect of LPS on Glucose, Lactate and Inflammatory Markers in the Lungs of Normal and Diabetic Mice.Journal of pulmonary & respiratory medicine · 2017Article
- Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface.Particle and fibre toxicology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary surfactant spreads on the thin ( approximately 0.1 microm) liquid layer that lines the alveoli, forming a film that reduces surface tension and allows normal respiration. Pulmonary surfactant deposited in vitro on liquid layers that are several orders of magnitude thicker, however, does not reach the low surface tensions ( approximately 0.001 N/m) achieved in the lungs during exhalation when the surfactant film compresses. This is due to collapse, a surface phase transition during which the surfactant film, rather than decreasing surface tension by increasing its surface density, becomes thicker at constant surface tension ( approximately 0.024 N/m). Formation of the collapse phase requires transport of surfactant to collapse sites, and this transport can be hindered in thinner liquid layers by viscous resistance to motion. Our objective is to determine the effect of the liquid-layer thickness on surfactant transport, which might affect surfactant collapse. To this end, we developed a mathematical model that accounts for the effect of the liquid-layer thickness on surfactant transport, and focused on surfactant spreading and collapse. Model simulations showed a marked decrease in collapse rates for thinner liquid layers, but this decrease was not enough to completely explain differences in surfactant film behavior between in vitro and in situ experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.