ReviewBiochimica et biophysica acta2008
Visualizing chromatin dynamics in intact cells.
Review in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Considering Abundance, Affinity, and Binding Site Availability in the NF-κB Target Selection Puzzle.Frontiers in immunology · 2019Review
- 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?Genome biology · 2016Review
- Formaldehyde crosslinking: a tool for the study of chromatin complexes.The Journal of biological chemistry · 2015Review
- Histone exchange, chromatin structure and the regulation of transcription.Nature reviews. Molecular cell biology · 2015Review
- The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules.Nature structural & molecular biology · 2011Article
- The three Rs of transcription: recruit, retain, and recycle.Molecular cell · 2010Article
- Nucleosome positioning: how is it established, and why does it matter?Developmental biology · 2010Review
- Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.Journal of mammary gland biology and neoplasia · 2010Review
- Article
- Capturing the dynamic epigenome.Genome biology · 2010Review
- Insights from genomic profiling of transcription factors.Nature reviews. Genetics · 2009Review
- Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation.Molecular endocrinology (Baltimore, Md.) · 2009Review
- Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity.Journal of cell science · 2009Article
- Dynamic access of the glucocorticoid receptor to response elements in chromatin.The international journal of biochemistry & cell biology · 2009Review
- Live cell imaging and systems biology.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin and associated regulatory proteins regulate gene expression in the natural environment of the intact cell nucleus. Specific combinations of DNA-binding transcription factors and recruited coregulatory proteins alter the conformation of chromatin at promoters and enhancers of target genes to stimulate or repress transcription. The dynamic nature of the regulatory proteins active in these processes allows the cell to modulate gene expression very rapidly, an important feature in many physiological processes. Live cell imaging and photobleaching studies of fluorescently-tagged proteins reveal that many transcription factors and other chromatin-associated proteins rapidly move through the nucleoplasm. Transcription factors also transiently interact with specific regulatory sequences in chromatin, suggesting that gene activation does not require the formation of stable long-lived regulatory complexes on the chromatin. In this review we discuss how dynamic interactions allow transcriptional regulatory proteins find their targets within the nucleus, alter target chromatin structure, and modulate physiological gene expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.