ArticleOphthalmology2008
Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema.
Article in Ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.The Cochrane database of systematic reviews · 2015Pooled it
- Comparison of short-pulse subthreshold (532 nm) and infrared micropulse (810 nm) macular laser for diabetic macular edema.Scientific reports · 2021Trial
- Relationship between duration and extent of oedema and visual acuity outcome with ranibizumab in diabetic macular oedema: A post hoc analysis of Protocol I data.Eye (London, England) · 2020Trial
- Predicting optical coherence tomography-derived diabetic macular edema grades from fundus photographs using deep learning.Nature communications · 2020Trial
- ASSOCIATION BETWEEN EARLY ANATOMIC RESPONSE TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY AND LONG-TERM OUTCOME IN DIABETIC MACULAR EDEMA: An Independent Analysis of Protocol i Study Data.Retina (Philadelphia, Pa.) · 2019Trial
- Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diabetic macular edema.Indian journal of ophthalmology · 2013Trial
- Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography.American journal of ophthalmology · 2011Trial
- Selective retina therapy (SRT) for clinically significant diabetic macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Trial
- The course of response to focal/grid photocoagulation for diabetic macular edema.Retina (Philadelphia, Pa.)Trial
- Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging.Translational vision science & technology · 2026Article
- Article
- Beyond Anti-VEGF: Toward Integrated Precision Care in Diabetic Retinal Disease.Pharmaceutics · 2026Review
- Optical Coherence Tomography Biomarkers as Potential Predictors for Visual Function and Response to Intravitreal Therapy in Diabetic Macular Edema.Journal of vitreoretinal diseases · 2026Article
- Impact of baseline visual acuity, time-in-range and early treatment on functional outcomes in DMO: insights from the IRISS outcomes.Eye (London, England) · 2026Article
- Article
- Correlation between Humphrey Field Analyser perimetric outcomes and macular thickness in diabetic retinopathy patients, diabetic individuals without retinopathy, and control subjects in Trinidad and Tobago.BMC research notes · 2026Article
- Artificial intelligence for early detection of diabetes mellitus complications via retinal imaging.Journal of diabetes and metabolic disorders · 2025Review
- Intensive Glycemic Management Is Associated With Reduced Retinal Structure Abnormalities on Ocular Coherence Tomography in the DCCT/EDIC Study.Diabetes care · 2024Article
- Association of serum lipid profile and other systemic risk factors with retinal hard exudates in diabetic retinopathy.International ophthalmology · 2024Article
- Retinal Thickness Deviation: A New OCT Parameter for Assessing Diabetic Macular Edema.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate optical coherence tomography (OCT) measurements and methods of analysis of OCT data in studies of diabetic macular edema (DME).
designAssociations of pairs of OCT variables and results of 3 analysis methods using data from 2 studies of DME.
participantsTwo hundred sixty-three subjects from a study of modified Early Treatment of Diabetic Retinopathy Study (mETDRS) versus modified macular grid (MMG) photocoagulation for DME and 96 subjects from a study of diurnal variation of DME.
methodsCorrelations were calculated for pairs of OCT variables at baseline and for changes in the variables over time. Distribution of OCT measurement changes, predictive factors for OCT measurement changes, and treatment group outcomes were compared when 3 measures of change in macular thickness were analyzed: absolute change in retinal thickness, relative change in retinal thickness, and relative change in retinal thickening.
main outcome measuresConcordance of results using different OCT variables and analysis methods.
resultsCenter point thickness correlated highly with central subfield mean thickness (CSMT) at baseline (0.98-0.99). The distributions of changes in CSMT were approximately normally distributed for absolute change in retinal thickness and relative change in retinal thickness, but not for relative change in retinal thickening. Macular thinning in the mETDRS group was significantly greater than in the MMG group when absolute change in retinal thickness was used, but not when relative change in thickness and relative change in thickening were used. Relative change in macular thickening provides unstable data in eyes with mild degrees of baseline thickening, unlike the situation with absolute or relative change in retinal thickness.
conclusionsCentral subfield mean thickness is the preferred OCT measurement for the central macula because of its higher reproducibility and correlation with other measurements of the central macula. Total macular volume may be preferred when the central macula is less important. Absolute change in retinal thickness is the preferred analysis method in studies involving eyes with mild macular thickening. Relative change in thickening may be preferable when retinal thickening is more severe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.