ArticleTrends in immunology2008
Regulation of autoimmune arthritis by self-heat-shock proteins.
Article in Trends in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review.Cells · 2021Review
- Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Modulation of Adjuvant Arthritis by Cellular and Humoral Immunity to Hsp65.Frontiers in immunology · 2016Review
- The danger theory: 20 years later.Frontiers in immunology · 2012Article
- Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.The open inflammation journal · 2011Article
- A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice.PloS one · 2011Article
- Identification of immunological parameters associated with the alveolar bone level in periodontal patients.Journal of periodontal & implant science · 2010Article
- Administration of Mycobacterium leprae rHsp65 aggravates experimental autoimmune uveitis in mice.PloS one · 2009Article
- Heat-shock proteins can promote as well as regulate autoimmunity.Autoimmunity reviews · 2009Review
- The determinants of susceptibility/resistance to adjuvant arthritis in rats.Arthritis research & therapy · 2009Review
- Self heat-shock protein 65-mediated regulation of autoimmune arthritis.Journal of autoimmunityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Heat-shock proteins (hsps) are highly conserved and immunogenic, and they are generally perceived to be attractive initiators or targets of a pathogenic immune response, and as such, have been implicated in the pathogenesis of autoimmune arthritis. However, studies in animal models and arthritis patients have unraveled the disease-regulating attributes of self-hsp65. We propose that the self-hsp65 induces a protective and beneficial immune response because of its ubiquitous distribution, stress inducibility and participation in tolerogenic processes. By contrast, the foreign hsp65 that does not influence the above processes and that resides admixed with microbial ligands for innate receptors generates an inflammatory pathogenic response. The regulatory properties of self-hsps need be fully explored and might be used for therapeutic purposes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.