Trial reportPsychoneuroendocrinology2008
Facial emotion recognition and amygdala activation are associated with menstrual cycle phase.
Trial report in Psychoneuroendocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 182 citations in OpenAlex.
- Lifespan exposure to hormone therapies and structural brain morphometry in older women.NeuroImage · 2026Trial
- Hormonal mechanisms of women's risk in the face of traumatic stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial.Psychopharmacology · 2025Trial
- Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study.Translational psychiatry · 2015Trial
- The correlations between psychotic symptoms and childhood maltreatment as well as sex differences in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- A bidirectional 2-sample Mendelian randomization study of depressed mood and premature ovarian insufficiency.Medicine · 2026Article
- HappyMums mobile application study protocol: use of a smartphone application to gather data predictive of antenatal depression.BMJ open · 2026Observational
- Olfactory perception and wellbeing across hormonal contraceptive users and menstrual cycle phases.Frontiers in human neuroscience · 2026Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Specialization of amygdala subregions in emotion processing.Human brain mapping · 2024Article
- Estrogen predicts multimodal emotion recognition accuracy across the menstrual cycle.PloS one · 2024Article
- Genetic Influences on Cognitive Dysfunction in Schizophrenia.Current topics in behavioral neurosciences · 2023Article
- Does the interplay of emotion-related personality traits and reproductive hormones predict individual variation in emotion recognition?PloS one · 2023Article
- Similarities and differences in the induction and regulation of the negative emotions fear and disgust: A functional near infrared spectroscopy study.Scandinavian journal of psychology · 2022Article
- Oral Contraceptives Modulate the Relationship Between Resting Brain Activity, Amygdala Connectivity and Emotion Recognition - A Resting State fMRI Study.Frontiers in behavioral neuroscience · 2022Article
- The impact of face masks on emotion recognition performance and perception of threat.PloS one · 2022Article
- How Sleep-Deprived People See and Evaluate Others' Faces: An Experimental Study.Nature and science of sleep · 2022Article
- The regulatory roles of progesterone and estradiol on emotion processing in women.Cognitive, affective & behavioral neuroscience · 2021Article
- The Specificities of Elite Female Athletes: A Multidisciplinary Approach.Life (Basel, Switzerland) · 2021Review
- Pupil dilation reflects the authenticity of received nonverbal vocalizations.Scientific reports · 2021Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Converging evidence has accumulated that menstrual cycle and thus hormonal levels can affect emotional behavior, in particular facial emotion recognition. Here we explored the association of ovarian hormone levels and amygdala activation during an explicit emotion recognition task in two groups of healthy young females: one group was measured while in their follicular phase (n=11) and the other during their luteal phase (n=11). Using a 3T scanner in combination with a protocol specifically optimized to reliably detect amygdala activation we found significantly stronger amygdala activation in females during their follicular phase. Also, emotion recognition performance was significantly better in the follicular phase. We observed significant negative correlations between progesterone levels and amygdala response to fearful, sad and neutral faces, further supporting a significant modulation of behavior and neural response by hormonal changes during the menstrual cycle. From an evolutionary point of view this significant influence of ovarian hormone level on emotion processing and an important neural correlate, the amygdala, may enable a higher social sensitivity in females during their follicular phase, thus facilitating socio-emotional behavior (and social interaction) which may possibly facilitate mating behavior as well.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.