ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Cardiovascular risk, obesity, and myocardial blood flow in postmenopausal women.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The prognostic value of quantitative myocardial blood flow and flow reserve by dynamic CZT-SPECT for major adverse cardiovascular events.European journal of nuclear medicine and molecular imaging · 2026Article
- Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries.Circulation research · 2022Review
- Capillary Rarefaction in Obesity and Metabolic Diseases-Organ-Specificity and Possible Mechanisms.Cells · 2020Review
- Quantification of PET Myocardial Blood Flow.Current cardiology reports · 2019Review
- Coronary Microvascular Dysfunction and Cardiovascular Risk in Obese Patients.Journal of the American College of Cardiology · 2018Observational
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Myocardial blood flow: Putting it into clinical perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response.Current vascular pharmacology · 2014Review
- Article
- Obesity and statins are both independent predictors of enhanced coronary arteriolar dilation in patients undergoing heart surgery.Journal of cardiothoracic surgery · 2013Article
- Non-invasive quantification of coronary vascular dysfunction for diagnosis and management of coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- The influence of insulin resistance, obesity, and diabetes mellitus on vascular tone and myocardial blood flow.Current cardiology reports · 2012Review
- Microvascular responsiveness in obesity: implications for therapeutic intervention.British journal of pharmacology · 2012Review
- Are people with normal radionuclide perfusion imaging studies better-off if they are obese?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Detecting the impact of emerging cardiovascular risk factors: the role of positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was designed to determine whether overweight or obese status is independently associated with myocardial flow reserve (MFR), an established predictor of cardiovascular mortality, in a group of postmenopausal women with no previous cardiovascular disease. Postmenopausal women are the largest group of overweight and physically inactive individuals in the United States. Increased body mass index (BMI) is consistently associated with increased cardiovascular mortality in this population. Whether this is because of obesity itself or the accompanying increase in cardiovascular risk factors (CRFs) remains controversial.
methodsWe examined the relationship of myocardial blood flow (MBF), coronary vascular resistance, and MFR to BMI in 60 postmenopausal women with no coronary heart disease. Subjects underwent dynamic N-13 ammonia positron emission tomography for the measurement of MBF and MFR. Baseline demographics, CRF, and hemodynamic parameters were recorded for each subject. Datasets were divided into 3 groups according to BMI: normal (18 to 24), overweight (25 to 29), and obese (>or=30).
resultsThe overweight and obese groups showed significantly higher resting MBF and lower MFR than the normal-weight group (both P < .001), even after adjusting for CRF. A further analysis of subjects without any CRF (n = 35) showed that the MFR remained significantly lower in the obese compared with normal-weight subjects (P = .05). Levels of known markers of vascular inflammation (high-sensitivity C-reactive protein and homocysteine) and high-density lipoprotein cholesterol levels correlated with declining MFR.
conclusionsThese findings provide a mechanistic link between obesity and coronary heart disease in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.