ArticleBMC chemical biology2008
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.
Article in BMC chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule.Computational and structural biotechnology journal · 2022Review
- Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy.PLoS pathogens · 2021Article
- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer.Reviews of physiology, biochemistry and pharmacology · 2021Review
- General Aspects of Metal Ions as Signaling Agents in Health and Disease.Biomolecules · 2020Review
- Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.Heart rhythm · 2019Article
- Article
- ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.International journal of molecular sciences · 2016Review
- Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.PLoS pathogens · 2015Article
- Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Role of calmodulin-calmodulin kinase II, cAMP/protein kinase A and ERK 1/2 on Aeromonas hydrophila-induced apoptosis of head kidney macrophages.PLoS pathogens · 2014Article
- Differential gene expression in small and large rainbow trout derived from two seasonal spawning groups.BMC genomics · 2014Article
- Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway.PloS one · 2013Article
- Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells.Journal of natural medicines · 2012Article
- CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.Journal of neurochemistry · 2011Article
- Oxidized CaMKII: a "heart stopper" for the sinus node?The Journal of clinical investigation · 2011Article
- The role of CaMKII in calcium-activated death pathways in bone marrow B cells.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Beta-adrenergic receptor signaling in the heart: role of CaMKII.Journal of molecular and cellular cardiology · 2010Review
- The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.Cancer research · 2010Article
- Mechanisms of the beneficial effects of beta-adrenoceptor antagonists in congestive heart failure.Experimental and clinical cardiology · 2010Article
- Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.Journal of chemical biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracellular free calcium ([Ca2+]i) is a key element in apoptotic signaling and a number of calcium-dependent apoptosis pathways have been described. We here used a chemical biology strategy to elucidate the relative importance of such different pathways.
resultsA set of 40 agents ("bioprobes") that induce apoptosis was first identified by screening of a chemical library. Using p53, AP-1, NFAT and NF-kappaB reporter cell lines, these bioprobes were verified to induce different patterns of signaling. Experiments using the calcium chelator BAPTA-AM showed that Ca2+ was involved in induction of apoptosis by the majority of the bioprobes and that Ca2+ was in general required several hours into the apoptosis process. Further studies showed that the calmodulin pathway was an important mediator of the apoptotic response. Inhibition of calmodulin kinase II (CaMKII) resulted in more effective inhibition of apoptosis compared to inhibition of calpain, calcineurin/PP2B or DAP kinase. We used one of the bioprobes, the plant alkaloid helenalin, to study the role of CaMKII in apoptosis. Helenalin induced CaMKII, ASK1 and Jun-N-terminal kinase (JNK) activity, and inhibition of these kinases inhibited apoptosis.
conclusionOur study shows that calcium signaling is generally not an early event during the apoptosis process and suggests that a CaMKII/ASK1 signaling mechanism is important for sustained JNK activation and apoptosis by some types of stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.