ArticleCell proliferation2008
On-chip non-invasive and label-free cell discrimination by impedance spectroscopy.
Article in Cell proliferation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 74 citations in OpenAlex.
- Vertical Microfluidic Trapping System for Capturing and Simultaneous Electrochemical Detection of Cells.Sensors (Basel, Switzerland) · 2024Article
- Flow Cytometry: The Next Revolution.Cells · 2023Review
- A Simple Micromilled Microfluidic Impedance Cytometer with Vertical Parallel Electrodes for Cell Viability Analysis.Micromachines · 2023Article
- piRT-IFC: Physics-informed real-time impedance flow cytometry for the characterization of cellular intrinsic electrical properties.Microsystems & nanoengineering · 2023Article
- A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties.Biosensors · 2022Article
- Thin flexible lab-on-a-film for impedimetric sensing in biomedical applications.Scientific reports · 2022Article
- Evaluation of Lipid Accumulation Using Electrical Impedance Measurement under Three-Dimensional Culture Condition.Micromachines · 2019Article
- Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems.ACS chemical biology · 2018Review
- Applications of Bioimpedance Measurement Techniques in Tissue Engineering.Journal of electrical bioimpedance · 2018Article
- Microfluidic differential immunocapture biochip for specific leukocyte counting.Nature protocols · 2016Article
- Single Cell Electrical Characterization Techniques.International journal of molecular sciences · 2015Review
- Study of Paclitaxel-Treated HeLa Cells by Differential Electrical Impedance Flow Cytometry.Biosensors · 2014Article
- Electric impedance microflow cytometry for characterization of cell disease states.Lab on a chip · 2013Article
- Low intensity and frequency pulsed electromagnetic fields selectively impair breast cancer cell viability.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMany flow-cytometric cell characterization methods require costly markers and colour reagents. We present here a novel device for cell discrimination based on impedance measurement of electrical cell properties in a microfluidic chip, without the need of extensive sample preparation steps and the requirement of labelling dyes. MATERIALS AND METHODS,
resultsWe demonstrate that in-flow single cell measurements in our microchip allow for discrimination of various cell line types, such as undifferentiated mouse fibroblasts 3T3-L1 and adipocytes on the one hand, or human monocytes and in vitro differentiated dendritic cells and macrophages on the other hand. In addition, viability and apoptosis analyses were carried out successfully for Jurkat cell models. Studies on several species, including bacteria or fungi, demonstrate not only the capability to enumerate these cells, but also show that even other microbiological life cycle phases can be visualized.
conclusionsThese results underline the potential of impedance spectroscopy flow cytometry as a valuable complement to other known cytometers and cell detection systems.
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