ArticleThe American journal of pathology1991
Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. Time-lapse and image analysis.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 106 citations in OpenAlex.
- Charting the importance of filamin A posttranslational modifications.The Biochemical journal · 2024Review
- Changes in cytoarchitecture and mobility in B16F1 melanoma cells induced by 5-Br-2'-dU coincide with Rock2, miRNAs 138-5p and 455-3p reciprocal expressions.Biochemistry and biophysics reports · 2021Article
- Article
- Absence of RIPK3 predicts necroptosis resistance in malignant melanoma.Cell death & disease · 2015Article
- Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.Oncogene · 2015Article
- Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy.Cancer biology & therapy · 2014Article
- Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells.Cell death and differentiation · 2013Article
- Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma.Oncotarget · 2013Article
- Complex roles of filamin-A mediated cytoskeleton network in cancer progression.Cell & bioscience · 2013Article
- Decreased expression of nuclear p300 is associated with disease progression and worse prognosis of melanoma patients.PloS one · 2013Article
- Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-time.PloS one · 2012Article
- Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion.The American journal of pathology · 2010Article
- Review
- Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.The Journal of biological chemistry · 2010Article
- The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.Biomarkers in medicine · 2010Article
- RSK in tumorigenesis: connections to steroid signaling.Steroids · 2010Review
- Epac increases melanoma cell migration by a heparan sulfate-related mechanism.American journal of physiology. Cell physiology · 2009Article
- Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin.Biophysical journal · 2009Article
- Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes.International journal of cell biology · 2009Article
- Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis.Oncogene · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Random cell migration and actin organization in seven human primary, recurrent cutaneous, and metastatic melanoma cell lines were studied by time-lapse video recording and image analysis. The migration of over 800 randomly selected cells from the cell lines were recorded using an inverted microscope with an attached incubator housing. The fraction of cells with random migration rates greater than 10 microns/hour was 8% in an established primary melanoma cell line, 2% and 34% in two recurrent cutaneous melanoma cell lines, and 5%, 30%, 31%, and 60% in four metastatic cell lines. The three metastatic cell lines with significantly higher mean migration rates (P less than 0.001) were derived from lymph node metastases, whereas the fourth metastatic cell line was derived from a visceral metastasis. The cellular morphology and presence of cell nests in the original tissue correlated with in vitro cell morphology and the formation of colonies. The ability of cells to organize actin into stress fibers directly correlated with significantly higher random migration rates and lack of colony formation. Characterization of random migration rates and actin organization of human melanoma cells that are isolated from different stages of tumor progression may lend insight into metastasis.
Indexed as
Identifiers
1867326PMC1886079W1556944626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.