ReviewCardiovascular & hematological agents in medicinal chemistry2008
Role of cellular elements in thrombus formation and dissolution.
Review in Cardiovascular & hematological agents in medicinal chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 83 citations in OpenAlex.
- Intracranial venous thrombosis imaging by anatomical location: an educational review with mimics and diagnostic pitfalls.Insights into imaging · 2026Article
- Untensed fibronectin fibers: a novel hallmark of microthrombi.Frontiers in cardiovascular medicine · 2025Article
- Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 2-Secondary Immunodeficiencies.Healthcare (Basel, Switzerland) · 2024Review
- A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.Journal of biomechanical engineering · 2024Article
- Reperfusion Therapies in Acute Ischemic Stroke Beyond the Conventional Time Window: A Narrative Review.Cureus · 2023Review
- Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel.Clinical and translational science · 2022Article
- In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy.Pharmaceutics · 2020Article
- Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists.Clinical pharmacokinetics · 2020Review
- Development and validation of a high throughput whole blood thrombolysis plate assay.Scientific reports · 2017Article
- Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction.BioMed research international · 2016Article
- Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus.Cardiovascular diabetology · 2015Review
- Adult and cord blood endothelial progenitor cells have different gene expression profiles and immunogenic potential.Blood transfusion = Trasfusione del sangue · 2014Article
- Relationship between thrombus attenuation and different stroke subtypes.Neuroradiology · 2013Observational
- Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates.Scandinavian journal of trauma, resuscitation and emergency medicine · 2013Article
- Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components.Journal of thrombosis and haemostasis : JTH · 2013Article
- Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results.Journal of neuroinflammation · 2012Article
- Lytic resistance of fibrin containing red blood cells.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- IL-17A increases ADP-induced platelet aggregation.Biochemical and biophysical research communications · 2011Article
- Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution.Ultrasound in medicine & biology · 2011Article
- Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts?Neuroradiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although fibrin forms the core matrix of thrombi, their structure depends also on the cellular elements embedded in its meshwork. Platelets are essential in the initial stages of thrombus formation, because they adhere and aggregate at sites of blood vessel wall injury and then serve as a surface for coagulation reactions, the overall rate of which determines the final structure of fibrin. In addition, platelets affect fibrinolysis through their proteins and phospholipids, which modulate plasmin activity. Leukocytes form mixed aggregates with platelets and thus influence the structure of thrombi. After activation they secrete different proteases (elastase, cathepsin G, matrix metalloproteinases) that enhance the von Willebrand factor-dependent platelet adhesion. Leukocyte-derived enzymes, first of all elastase, effect fibrinolysis by direct digestion of fibrin or indirectly modulate it by partial degradation of zymogens and inhibitors of coagulation and fibrinolytic proteases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.