ArticleBurns : journal of the International Society for Burn Injuries2009
Insulin resistance, secretion and breakdown are increased 9 months following severe burn injury.
Article in Burns : journal of the International Society for Burn Injuries, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children.Critical care medicine · 2010Trial
- Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles.Critical care (London, England) · 2025Review
- Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury.Journal of proteome research · 2024Article
- Article
- Effects of early exercise training following severe burn injury: a randomized controlled trial.Burns & trauma · 2024Article
- Investigation of glucose, serum insulin levels, and insulin resistance in patients with major burn: a retrospective cross-sectional study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021Review
- Status of adult inpatient burn rehabilitation in Europe: Are we neglecting metabolic outcomes?Burns & trauma · 2021Article
- Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy.World journal of experimental medicine · 2017Review
- Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.The Journal of clinical endocrinology and metabolism · 2017Article
- The impact of extended bed rest on the musculoskeletal system in the critical care environment.Extreme physiology & medicine · 2015Review
- Bacterial respiratory tract infections are promoted by systemic hyperglycemia after severe burn injury in pediatric patients.Burns : journal of the International Society for Burn Injuries · 2014Article
- The impact of severe burns on skeletal muscle mitochondrial function.Burns : journal of the International Society for Burn Injuries · 2013Review
- Glucose metabolism during the early "flow phase" after burn injury.The Journal of surgical research · 2013Article
- Role of the PPAR-α agonist fenofibrate in severe pediatric burn.Burns : journal of the International Society for Burn Injuries · 2012Review
- Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study.Lancet (London, England) · 2012Article
- Is there a difference in clinical outcomes, inflammation, and hypermetabolism between scald and flame burn?Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Insulin resistance in the acute burn period has been well described, however, it is unknown if alterations in glucose metabolism persist beyond discharge from the acute injury. To measure the duration of insulin resistance following recovery from the acute burn injury, we performed a prospective cross-sectional study with a standard 2-h oral glucose tolerance test in 46 severely burned children at 6, 9 or 12 months following initial injury. Glucose uptake and insulin secretion were assessed following the glucose load. Results were compared to those previously published in healthy children. At 6 months after burn, the 2-h glucose concentration was significantly (P<0.001) greater than controls, and the area under the curve (AUC) of glucose was significantly higher compared to 12 months and to healthy children (P=0.027 and P<0.001, respectively). The 9-month AUC glucose was higher than controls (P<0.01). The 6-month 2-h insulin was significantly higher than controls, as was the AUC of insulin in all time points post-burn. The AUC of C-peptide was significantly greater at 6 months after injury compared to 9 and 12 months (P<0.01 for both). Increased 2h and AUC glucose and insulin indicate that glucose metabolism is still affected at 6 and 9 months after injury, and coincides with previously documented defects in bone and muscle metabolism at these time points. Insulin breakdown is also still increased in this population. Further study of this population is warranted to determine if specific treatment is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.