Evidence map›Paper›PMID 18672289›Full record

ArticleOphthalmology2008

High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repair.

Allison J Smith, David G Telander, Robert J Zawadzki, Stacey S Choi, Lawrence S Morse, John S Werner, Susanna S Park

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05747144 (Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05747144 unknown statusnot on this mapstarted 2021, after this paper: background citation

Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies: Biomarkers of Morpho-Functional Recovery by Artificial Intelligence

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2021 to 2025Enrolled100ConditionsMacular Holes, Epiretinal Membrane, Retinal Detachment, Macular DystrophiesArmsBiometry, Retinography (Color) + Autofluorescence (AF), OCT B-scan and OCT angiography (OCTA), Microperimetry, Electrophysiological exams
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 96 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Characteristics of spontaneous reattachment of rhegmatogenous retinal detachment: optical coherence tomography features and follow-up outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Imaging analysis with optical coherence tomography angiography after primary repair of macula-off rhegmatogenous retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Inner and outer central retinal findings after surgery for rhegmatogenous retinal detachment using different spectral-domain optical coherence tomography devices.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015
    Article
  17. Article
  18. Article
  19. Review
  20. Restoration of the photoreceptor layer and improvement of visual acuity in successfully treated optic disc pit maculopathy: a long follow-up study by optical coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Allison J SmithDepartment of Ophthalmology and Vision Science, University of California Davis Medical Center, Sacramento, California, USA.
David G Telander
Robert J Zawadzki
Stacey S Choi
Lawrence S Morse
John S Werner
Susanna S Park
University of California Davis Medical Center · US

Funding

Ophthalmic Imaging Using Adaptive Optics and OCTR01EY014743 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI WERNER, JOHN S · 2003 to 2012
$10.4M
NEI NIH HHS R01 EY014743PHS HHS 014743
6 · The paper itself

Abstract

objectiveTo evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1).

designProspective observational case series.

participantsSeventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant maculopathy on funduscopy.

methodsFD OCT with axial and transverse resolution of 4.5 mum and 10 to 15 mum, respectively, was used to obtain rapid serial B-scans of the macula, which were compared with that from Stratus OCT. The FD OCT B-scans were used to create a 3-dimensional volume, from which en face C-scans were created. Among 11 patients, MP-1 was performed to correlate morphologic changes with visual function.

main outcome measuresStratus OCT scans, FD OCT scans, and MP-1 data.

resultsStratus OCT and FD OCT images of the macula were obtained 3 to 30 months (mean 7 months) postoperatively in all eyes. Although Stratus OCT revealed photoreceptor disruption in 2 eyes (12%), FD OCT showed photoreceptor disruption in 13 eyes (76%). This difference was statistically significant (P<0.001, chi(2)). Both imaging modalities revealed persistent subretinal fluid in 2 eyes (12%) and lamellar hole in 1 eye. Among 7 subjects who had reliable MP-1 data, areas of abnormal function corresponded to areas of photoreceptor layer disruptions or persistent subretinal fluid in 5 subjects (71%); one subject had normal FD OCT and MP-1.

conclusionsPhotoreceptor disruption after macula-off RD repair is a common abnormality in the macula that is detected better with FD OCT than Stratus OCT. A good correlation between MP-1 abnormality and presence of photoreceptor disruption or subretinal fluid on FD OCT demonstrates that these anatomic abnormalities contribute to decreased visual function after successful repair.

Indexed as

Tomography, Optical CoherenceVisual Field TestsAdultAgedBody FluidsCryotherapyExudates and TransudatesFemaleFourier AnalysisHumansMacula LuteaMaleMiddle AgedPhotoreceptor Cells, VertebrateProspective StudiesRetinal Detachment

Identifiers

PMID18672289
PMCPMC2735404
OpenAlexW2031642519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.