ArticleFertility and sterility2009
Gene expression profiling of multiple leiomyomata uteri and matched normal tissue from a single patient.
Article in Fertility and sterility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- BCL6 (B-cell lymphoma 6) expression in adenomyosis, leiomyomas and normal myometrium.PloS one · 2025Article
- Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases.Virchows Archiv : an international journal of pathology · 2024Article
- Ulipristal acetate induces cell cycle delay and remodeling of extracellular matrix.International journal of molecular medicine · 2018Article
- Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women.Frontiers in genetics · 2018Article
- Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications.Reproductive sciences (Thousand Oaks, Calif.) · 2017Review
- Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma.Seminars in reproductive medicine · 2013Article
- Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells.PloS one · 2013Article
- An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas.PloS one · 2013Article
- Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop.Fertility and sterility · 2011Article
- Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder.Seminars in reproductive medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo identify differentially expressed genes between fibroid and adjacent normal myometrium in an identical hormonal and genetic background.
designArray analysis of three leiomyomata and matched adjacent normal myometrium in a single patient.
settingUniversity of Colorado Hospital. PATIENT(S): A single female undergoing medically indicated hysterectomy for symptomatic fibroids. INTERVENTIONS(S): mRNA isolation and microarray analysis, reverse-transcriptase polymerase chain reaction, Western blotting, and immunohistochemistry. MAIN OUTCOME MEASURE(S): Changes in mRNA and protein levels in leiomyomata and matched normal myometrium. RESULT(S): Expression of 197 genes was increased and 619 decreased significantly by at least twofold, in leiomyomata relative to normal myometrium. Expression profiles between tumors were similar and normal myometrial samples showed minimal variation. Changes in, and variation of, expression of selected genes were confirmed in additional normal and leiomyoma samples from multiple patients. CONCLUSION(S): Analysis of multiple tumors from a single patient confirmed changes in expression of genes described in previous, apparently disparate, studies, and identified novel targets. Gene expression profiles in leiomyomata are consistent with increased activation of mitogenic pathways and inhibition of apoptosis. Down-regulation of genes implicated in invasion and metastasis, of cancers, was observed in fibroids. This expression pattern may underlie the benign nature of uterine leiomyomata and may aid in the differential diagnosis of leiomyosarcoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.