ReviewAmerican journal of ophthalmology2008
The need for standardization of antiretinal antibody detection and measurement.
Review in American journal of ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 68 citations in OpenAlex.
- Diagnosis and treatment of autoimmune retinopathy: review of current approaches.International ophthalmology · 2025Review
- Commercial immunoassays in paraneoplastic neurological syndromes: an Australian laboratory perspective.Frontiers in neurology · 2025Article
- Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Destructive inflammatory reaction after an autologous retinal pigment epithelium and choroid transplantation: no detection of an auto-immune response.Journal of ophthalmic inflammation and infection · 2022Article
- Cancer-associated retinopathy preceding the diagnosis of a pulmonary carcinoid tumour.BMJ case reports · 2020Article
- Intravitreal Dexamethasone Implant with Plasma Autoantibody Monitoring for Cancer-associated Retinopathy.Korean journal of ophthalmology : KJO · 2019Article
- The effect of autoimmune retinopathy on retinal vessel oxygen saturation.Eye (London, England) · 2018Article
- Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients.Journal of neuroimmunology · 2018Article
- Autoimmune Retinopathy: Current Concepts and Practices (An American Ophthalmological Society Thesis).Transactions of the American Ophthalmological Society · 2017Review
- B Cell Anomalies in Autoimmune Retinopathy (AIR).Investigative ophthalmology & visual science · 2017Article
- Consensus on the Diagnosis and Management of Nonparaneoplastic Autoimmune Retinopathy Using a Modified Delphi Approach.American journal of ophthalmology · 2016Article
- Cancer-associated retinopathy as the leading symptom in colon cancer.Clinical case reports · 2016Article
- Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.PloS one · 2016Article
- The enigma of autoimmune retinopathy.International ophthalmology clinics · 2015Review
- Autoimmune retinopathy.American journal of ophthalmology · 2014Review
- Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease?Autoimmune diseases · 2014Review
- Outer retinal structure in patients with acute zonal occult outer retinopathy.American journal of ophthalmology · 2012Article
- Autoimmune retinopathy in systemic lupus erythematosus: histopathologic features.The open ophthalmology journal · 2009Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeTo review the current literature on the detection and measurement of antiretinal antibodies.
designCollaborative essay.
methodsLiterature review and interpretation.
resultsThere is strong evidence to suggest a role for antiretinal antibodies, particularly those targeting recoverin and alpha-enolase, in the pathogenesis of autoimmune retinopathy (AIR). Additionally, numerous other autoantibodies have been described as putative mediators of retinal degeneration and more remain to be discovered. However, assay methods described in the literature by many laboratories for the detection of circulating antiretinal antibodies have been varied and diverse, making it difficult to interpret and compare their results.
conclusionsThere is currently little standardization of laboratory methods used to detect and monitor antiretinal antibodies. To measure and monitor levels of circulating antiretinal antibodies optimally in patients with AIR, development of standardized assays with stringent internal controls is required. A multicenter collaborative and validation effort is encouraged to reach a consensus on this issue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.