Evidence map›Paper›PMID 18672032›Full record

ArticleNeuroscience2008

BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats.

Z Ying, R R Roy, H Zhong, S Zdunowski, V R Edgerton, F Gomez-Pinilla

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01538693 (Molecular Markers of Neuroplasticity During High-Intensity Exercise in Subjects With Incomplete Spinal Cord Injury), which is not on this map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01538693 nacompletednot on this mapstarted 2011, after this paper: background citation

Molecular Markers of Neuroplasticity During High-Intensity Exercise in Subjects With Incomplete Spinal Cord Injury

TypeinterventionalSponsorT. George HornbyRan2011 to 2015Enrolled30ConditionsSpinal Cord InjuryArmsescitalopram oxalate, Cyproheptadine, sugar pill, Graded intensity exercise
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Oxidative Stress in Brain Function.Antioxidants (Basel, Switzerland) · 2025
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  15. Neural regeneration research · 2018
    Article
  16. Review
  17. Review
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  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Z YingDepartment of Physiological Science, University of California, Los Angeles, CA 90095-1527, USA.
R R Roy
H Zhong
S Zdunowski
V R Edgerton
F Gomez-Pinilla
University of California, Los Angeles · US

Funding

USE DEPENDENT MOLECULAR MODULATION OF RAT HINDLIMB MUSCLESP01NS016333 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROY, ROLAND R · 1985 to 2007
$9.9M
Restoration of Homeostasis After Brain TraumaR01NS050465 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2005 to 2019
$5.5M
NINDS NIH HHS NS16333NINDS NIH HHS NS50465NINDS NIH HHS P01 NS016333NINDS NIH HHS R01 NS050465
6 · The paper itself

Abstract

Clinical evidence indicates that motor training facilitates functional recovery after a spinal cord injury (SCI). Brain-derived neurotrophic factor (BDNF) is a powerful synaptic facilitator and likely plays a key role in motor and sensory functions. Spinal cord hemisection decreases the levels of BDNF below the injury site, and exercise can counteract this decrease [Ying Z, Roy RR, Edgerton VR, Gomez-Pinilla F (2005) Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Exp Neurol 193:411-419]. It is not clear, however, whether the exercise-induced increases in BDNF play a role in mediating the recovery of locomotion after a SCI. We performed a lateral cervical ( approximately C4) hemisection in adult rats. Seven days after hemisection, the BDNF inhibitor trkB IgG was injected into the cervical spinal cord below the lesion ( approximately C5-C6). Half of the rats were exposed to voluntary running wheels for 14 days. Locomotor ability was assessed by determining the symmetry between the contralateral (unaffected) vs. the ipsilateral (affected) forelimb at the most optimum treadmill speed for each rat. Sedentary and exercised rats with BDNF inhibition showed a higher level of asymmetry during the treadmill locomotion test than rats not treated with the BDNF inhibitor. In hemisected rats, exercise normalized the levels of molecules important for synaptic function, such as cyclic AMP response element binding protein (CREB) and synapsin I, in the ipsilateral cervical enlargement, whereas the BDNF blocker lessened these exercise-associated effects. The results indicate that BDNF levels play an important role in shaping the synaptic plasticity and in defining the level of recovery of locomotor performance after a SCI.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCREB-Binding ProteinExercise TestFunctional LateralityGAP-43 ProteinHumansImmunoglobulin GMaleMotor ActivityNerve Growth FactorsPhysical Conditioning, AnimalPsychomotor PerformanceRatsRats, Sprague-DawleyReceptor, trkBBrain-Derived Neurotrophic FactorCREB-Binding ProteinGAP-43 ProteinImmunoglobulin GNerve Growth Factorsneurotropin 3, mouseReceptor, trkBRNA, MessengerSynapsins

Identifiers

PMID18672032
PMCPMC2805664
OpenAlexW1997411649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.