ArticleVirology journal2008
Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
120 citing papers in PubMed, 289 citations in OpenAlex.
- Detection of circovirus and herpesvirus co-infection in suddenly dead.Veterinary research communications · 2026Article
- Molecular detection and characterization of Parrot Bornavirus 4 (PaBV-4) in captive psittacine birds in India.Scientific reports · 2026Article
- An Assessment of Anti-Ganglioside Antibodies for the Diagnosis of Avian Ganglioneuritis and Potential Correlation with Gross Lesions, Microscopic Findings and Serologic Titers in Cockatiels Challenged with Parrot Bornavirus.Animals : an open access journal from MDPI · 2026Article
- Occurrence of bornaviruses, circoviruses and polyomaviruses in necropsy samples from parrots in Poland (2014-2024).Journal of veterinary research · 2026Article
- Idiopathic achalasia: unraveling the etiology and pathogenesis of an inflammatory disease.Gastroenterology report · 2026Review
- Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses.Microbiology and immunology · 2026Article
- Molecular detection and genetic characterization of parrot bornavirus in captive psittacine birds in Thailand.The Journal of veterinary medical science · 2025Article
- Safety of ribavirin in cockatiels (Nymphicus hollandicus) - a preliminary study.Scientific reports · 2025Article
- Use of Cyclosporine and Itraconazole as Palliative Treatment for Proventricular Dilatation Disease in Psittacine Birds.Veterinary sciences · 2025Article
- Pathogenesis of aquatic bird bornavirus 1 in turkeys of different age.Npj viruses · 2025Article
- Distribution of lesions in psittacine birds naturally infected with parrot bornavirus in Japan.The Journal of veterinary medical science · 2024Article
- Viral Diagnosis in Psittacine Birds: A Scientometric and Systematic Review of 47 Years.Animals : an open access journal from MDPI · 2024Review
- Surveillance of Parrot Bornavirus in Taiwan CaptiveViruses · 2024Article
- Antiviral Chemotherapy in Avian Medicine-A Review.Viruses · 2024Review
- Genetic trends in parrot Bornavirus: a clinical analysis.The Journal of veterinary medical science · 2024Article
- Evolutionary Analysis of a Parrot Bornavirus 2 Detected in a Sulphur-Crested Cockatoo (Animals : an open access journal from MDPI · 2023Article
- Molecular detection of bornavirus in parrots imported to China in 2022.BMC veterinary research · 2023Article
- Experimental pathogenesis of aquatic bird bornavirus 1 in Pekin ducks.Scientific reports · 2023Article
- Emerging and Novel Viruses in Passerine Birds.Microorganisms · 2023Review
- Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation.Journal of virology · 2023Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundProventricular dilatation disease (PDD) is a fatal disorder threatening domesticated and wild psittacine birds worldwide. It is characterized by lymphoplasmacytic infiltration of the ganglia of the central and peripheral nervous system, leading to central nervous system disorders as well as disordered enteric motility and associated wasting. For almost 40 years, a viral etiology for PDD has been suspected, but to date no candidate etiologic agent has been reproducibly linked to the disease.
resultsAnalysis of 2 PDD case-control series collected independently on different continents using a pan-viral microarray revealed a bornavirus hybridization signature in 62.5% of the PDD cases (5/8) and none of the controls (0/8). Ultra high throughput sequencing was utilized to recover the complete viral genome sequence from one of the virus-positive PDD cases. This revealed a bornavirus-like genome organization for this agent with a high degree of sequence divergence from all prior bornavirus isolates. We propose the name avian bornavirus (ABV) for this agent. Further specific ABV PCR analysis of an additional set of independently collected PDD cases and controls yielded a significant difference in ABV detection rate among PDD cases (71%, n = 7) compared to controls (0%, n = 14) (P = 0.01; Fisher's Exact Test). Partial sequence analysis of a total of 16 ABV isolates we have now recovered from these and an additional set of cases reveals at least 5 distinct ABV genetic subgroups.
conclusionThese studies clearly demonstrate the existence of an avian reservoir of remarkably diverse bornaviruses and provide a compelling candidate in the search for an etiologic agent of PDD.
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