Trial reportBritish journal of haematology2008
Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study.
Trial report in British journal of haematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01033227 (A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease
Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Pharmacokinetics, pharmacodynamics, safety, and tolerability of nebulized sodium nitrite (AIR001) following repeat-dose inhalation in healthy subjects.Clinical pharmacokinetics · 2015Trial
- Nitrosyl hemoglobin formation from nitrite in normal and sickle blood.Free radical biology & medicine · 2024Article
- The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments.Nitric oxide : biology and chemistry · 2020Article
- cGMP modulation therapeutics for sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Crises in Sickle Cell Disease.Chest · 2016Review
- Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.The Lancet. Haematology · 2014Article
- Role of blood and vascular smooth muscle in the vasoactivity of nitrite.American journal of physiology. Heart and circulatory physiology · 2014Article
- Role of nitrite in regulation of fetal cephalic circulation in sheep.The Journal of physiology · 2014Article
- Article
- Inorganic nitrite supplementation for healthy arterial aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions.PloS one · 2014Article
- Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics.Antioxidants & redox signaling · 2013Review
- Malaria biology and disease pathogenesis: insights for new treatments.Nature medicine · 2013Review
- Article
- Inorganic nitrite therapy: historical perspective and future directions.Free radical biology & medicine · 2011Review
- Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.American journal of physiology. Heart and circulatory physiology · 2010Article
- Nitrite directly vasodilates hypoxic vasculature via nitric oxide-dependent and -independent pathways.British journal of pharmacology · 2009Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In addition to vaso-occlusion by sickled erythrocytes, the pathophysiology of sickle cell disease (SCD) is compounded by the diminished bioavailability of nitric oxide (NO), associated with vasoconstriction, endothelial activation and cell adhesion. We tested the ability of sodium nitrite, which can be converted to NO by deoxyhaemoglobin at acid pH and low oxygen tension, to improve blood flow in patients with SCD. In a phase I/II clinical trial, sodium nitroprusside, NG-monomethyl-L-arginine, and sodium nitrite were infused sequentially into the brachial artery in 14 patients at steady state. In a dose-dependent manner, sodium nitrite infusion rates of 0.4, 4 and 40 micromol/min into the brachial artery augmented mean venous plasma nitrite concentrations (P < 0.0001) and stimulated forearm blood flow up to 77 +/- 11% above baseline (P < 0.0001), measured by venous occlusion strain gauge plethysmography. This nitrite response was blunted significantly compared to controls without SCD, as previously seen with other NO donors. Sodium nitrite infusions were well tolerated without hypotension, clinically significant methaemoglobinaemia or other untoward events. The unique pharmacological properties of nitrite as a hypoxia-potentiated vasodilator and cytoprotective agent in the setting of ischaemia-reperfusion injury make this anion a plausible NO donor for future clinical trials in SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.