ArticleJournal of molecular histology2008
Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats.
Article in Journal of molecular histology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Genomic Instability in the Lymphocytes of Dogs with Squamous Cell Carcinoma.Animals : an open access journal from MDPI · 2024Article
- Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.Medical oncology (Northwood, London, England) · 2018Article
- Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam CT.Dento maxillo facial radiology · 2018Article
- Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium.Environmental science and pollution research international · 2014Article
- The influence of sleep deprivation on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.Dental research journal · 2013Article
- The influence of sleep deprivation and obesity on DNA damage in female Zucker rats.Clinics (Sao Paulo, Brazil) · 2013Article
- Cytogenetic biomonitoring in oral mucosa cells following dental X-ray.Dento maxillo facial radiology · 2012Review
- Genomic instability in blood cells from murine model of mucopolysaccharidosis type I.Journal of molecular histology · 2011Article
- Differential response related to genotoxicity in multiple organs of cirrhotic rats.Hepatology international · 2011Article
- Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography.Clinical oral investigations · 2011Article
- The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.Journal of molecular histology · 2010Article
- Expression of gap junctional protein connexin43 during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.Journal of molecular histology · 2009Article
- No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.Journal of molecular histology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was undertaken to investigate the genomic instability on blood cells during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis by means of single cell gel (comet) and micronucleus assays. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, genetic damage was found in blood cells as depicted by the mean tail moment and an increase of micronucleated polychromatic erythrocytes. After 12 and 20 weeks treatment, the same picture occurred, being the strong effect observed in the micronucleus induction. These periods correspond to pre-neoplastic lesions and well-differentiated squamous cell carcinomas, respectively. Taken together, our results support the idea that genomic instability on blood cells appears to be associated with the risk and progression of oral cancer, being a reliable tool for detecting early systemic conditions of malignancy.
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Registered trials
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