ReviewImmunologic research2008
NF-kappaB pathways in the immune system: control of the germinal center reaction.
Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Activation-induced cytidine deaminase in tertiary lymphoid structures: dual roles and implications in cancer prognosis.Frontiers in oncology · 2025Review
- Article
- Herpesvirus-Entry Mediator Inhibits the NF-Journal of tissue engineering and regenerative medicine · 2024Article
- Cyclic Helix B Peptide Prolongs Skin Allograft SurvivalFrontiers in immunology · 2021Article
- The effect of bone inhibitors on periosteum-guided cartilage regeneration.Scientific reports · 2020Article
- Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.Nature communications · 2018Article
- Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Review
- Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host.Frontiers in microbiology · 2016Review
- Uncovering MicroRNA Regulatory Hubs that Modulate Plasma Cell Differentiation.Scientific reports · 2015Article
- LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.EMBO reports · 2015Article
- Local administration of IKK small molecule inhibitor may enhance fracture healing in osteoporosis patient.International journal of clinical and experimental medicine · 2015Article
- A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.PloS one · 2014Article
- A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome.Sleep · 2013Article
- NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Impaired B cell development and function in the absence of IkappaBNS.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The NF-kappaB signaling pathway plays a critical role in regulating innate and adaptive immunity. This is clearly evident as mouse models deficient for numerous NF-kappaB subunits and upstream activators exhibit defects in the immune system ranging from impaired development of lymphocytes to defective adaptive immune responses. In this review, we focus on the role that NF-kappaB plays in the germinal center (GC) reaction. Specifically, we discuss the major NF-kappaB subunits and the IkappaB homolog, Bcl-3. Recent findings reveal that Bcl-6, an unrelated transcriptional repressor, is functionally similar to Bcl-3 as both factors may suppress p53 activity to allow for efficient GC formation to occur. We discuss potential mechanisms of action for Bcl-3 and Bcl-6 in this highly complex, but important process of B-cell affinity maturation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.