ArticleNeoplasia (New York, N.Y.)2008
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma.
Article in Neoplasia (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
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- A network-based analysis to identify a piRNA-target signature related to colorectal cancer prognosis: in silico and in vitro study.Discover oncology · 2025Article
- Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine.HGG advances · 2023Article
- A Pan-Cancer Analysis of the Oncogenic Role ofFrontiers in genetics · 2022Article
- BCL7A as a novel prognostic biomarker for glioma patients.Journal of translational medicine · 2021Article
- MiR-501-3p promotes osteosarcoma cell proliferation, migration and invasion by targeting BCL7A.Human cell · 2021Article
- Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress.American journal of cancer research · 2021Article
- BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling.American journal of cancer research · 2018Article
- The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.PLoS genetics · 2015Article
- Constitutional and somatic deletions of the Williams-Beuren syndrome critical region in non-Hodgkin lymphoma.Journal of hematology & oncology · 2014Article
- SWI/SNF chromatin remodeling complexes and cancer.American journal of medical genetics. Part C, Seminars in medical genetics · 2014Review
- Article
- Molecular fingerprinting reflects different histotypes and brain region in low grade gliomas.BMC cancer · 2013Article
- Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.PloS one · 2013Article
- The molecular biology of WHO grade I astrocytomas.Neuro-oncology · 2012Review
- MAPK pathway activation in pilocytic astrocytoma.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Dinosaurs and ancient civilizations: reflections on the treatment of cancer.Neoplasia (New York, N.Y.) · 2010Article
- Copy number variants at Williams-Beuren syndrome 7q11.23 region.Human genetics · 2010Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular pathogenesis of pediatric pilocytic astrocytoma (PA) is not well defined. Previous cytogenetic and molecular studies have not identified nonrandom genetic aberrations. To correlate differential gene expression and genomic copy number aberrations (CNAs) in PA, we have used Affymetrix GeneChip HG_U133A to generate gene expression profiles of 19 pediatric patients and the SpectralChip 2600 to investigate CNAs in 11 of these tumors. Hierarchical clustering according to expression profile similarity grouped tumors and controls separately. We identified 1844 genes that showed significant differential expression between tumor and normal controls, with a large number clearly influencing phosphatidylinositol and mitogen-activated protein kinase signaling in PA. Most CNAs identified in this study were single-clone alterations. However, a small region of loss involving up to seven adjacent clones at 7q11.23 was observed in seven tumors and correlated with the underexpression of BCL7B. Loss of four individual clones was also associated with reduced gene expression including SH3GL2 at 9p21.2-p23, BCL7A (which shares 90% sequence homology with BCL7B) at 12q24.33, DRD1IP at 10q26.3, and TUBG2 and CNTNAP1 at 17q21.31. Moreover, the down-regulation of FOXG1B at 14q12 correlated with loss within the gene promoter region in most tumors. This is the first study to correlate differential gene expression with CNAs in PA.
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