ArticleAdvances in urology2008
Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease.
Article in Advances in urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.Human genetics · 2015Trial
- AI-Supported Prediction of Vesicoureteral Reflux in Children Based on Cystoscopic Configuration of the Ureteric Orifice.Journal of clinical medicine · 2026Article
- Functional assessment of renal damage in children with primary vesicoureteral reflux.Frontiers in pediatrics · 2025Article
- Therapeutic Management of Children with Vesicoureteral Reflux.Journal of clinical medicine · 2023Article
- The Utility of Noninvasive Urinary Biomarkers for the Evaluation of Vesicoureteral Reflux in Children.International journal of molecular sciences · 2023Article
- Long term results of non-refluxing ureteral reimplantation in the pediatric population.Pediatric surgery international · 2023Article
- The importance of ambulatory blood pressure monitoring for diagnosing masked hypertension in patients with renal parenchymal scarring.Pediatric nephrology (Berlin, Germany) · 2023Article
- Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects.Journal of clinical medicine · 2023Review
- Is ultrasonography mandatory in all children at their first febrile urinary tract infection?Pediatric nephrology (Berlin, Germany) · 2021Article
- Application of data mining techniques to explore predictors of upper urinary tract damage in patients with neurogenic bladder.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Renal tissue oxygenation in children with chronic kidney disease due to vesicoureteral reflux.Pediatric nephrology (Berlin, Germany) · 2016Article
- Pathophysiology, Clinical Importance, and Management of Neurogenic Lower Urinary Tract Dysfunction Caused by Suprasacral Spinal Cord Injury.Journal of veterinary internal medicine · 2016Review
- Fatal Renal Failure in a Spinal Cord Injury Patient with Vesicoureteric Reflux Who Underwent Repeated Ureteric Reimplantations Unsuccessfully: Treatment Should Focus on Abolition of High Intravesical Pressures rather than Surgical Correction of Reflux.Case reports in urology · 2012Article
- Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
objectiveTo review the contribution of vesicoureteral reflux and reflux nephropathy to end-stage renal disease. DATA SOURCE: Published research articles and publicly available registries.
resultsVesicoureteral reflux (VUR) is commonly identified in pediatric patients and can be associated with reflux nephropathy (RN), chronic kidney disease (CKD), and rarely end-stage renal disease (ESRD). Patients with reduced GFR, bilateral disease, grade V VUR, proteinuria, and hypertension are more likely to progress to CKD and ESRD. Because progression to ESRD is rare in VUR and often requires many decades to develop, there are limited prospective, randomized, controlled trials available to direct therapy to prevent progression to ESRD.
conclusionsIdentification of patients with increased risk of progression to CKD and ESRD should be the goal of clinical, biochemical, and radiological evaluation of patients with VUR. Treatment of patients with VUR should be directed at preventing new renal injury and preserving renal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.