ArticleAmerican journal of epidemiology2008
Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children.
Article in American journal of epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Drivers of stunting reduction in Peru: a country case study.The American journal of clinical nutrition · 2020Pooled it
- Global causes of diarrheal disease mortality in children <5 years of age: a systematic review.PloS one · 2013Pooled it
- A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Pooled it
- Protection against diarrhea associated with Giardia intestinalis Is lost with multi-nutrient supplementation: a study in Tanzanian children.PLoS neglected tropical diseases · 2011Trial
- Effect of inoculation dose on infection kinetics and immune responses to Giardia.Scientific reports · 2025Article
- Comparative genomics of Giardia duodenalis sub-assemblage AI beaver (Be-2) and human (WB-C6) strains show remarkable homozygosity, sequence similarity, and conservation of VSP genes.Scientific reports · 2024Article
- How the gut parasitome affects human health.Therapeutic advances in gastroenterology · 2022Review
- Detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- A prevalence survey of enteral parasites in preschool children in the Mangochi District of Malawi.BMC infectious diseases · 2019Article
- Proliferation of Resident Macrophages Is Dispensable for Protection duringImmunoHorizons · 2019Article
- Article
- The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis.Trends in parasitology · 2017Review
- Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort.Journal of the Pediatric Infectious Diseases Society · 2017Article
- Detection of Intestinal Pathogens in River, Shore, and Drinking Water in Lima, Peru.Journal of genomics · 2017Article
- A Prospective Longitudinal Cohort to Investigate the Effects of Early Life Giardiasis on Growth and All Cause Diarrhea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Giardia duodenalis assemblages in Egyptian children with diarrhea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Advances in understanding Giardia: determinants and mechanisms of chronic sequelae.F1000prime reports · 2015Review
- Diarrhea in early childhood: short-term association with weight and long-term association with length.American journal of epidemiology · 2013Article
- Prevalence of giardiasis in children attending semi-urban daycare centres in Guatemala and comparison of 3 giardia detection tests.Journal of health, population, and nutrition · 2013Article
- Persistent G. lamblia impairs growth in a murine malnutrition model.The Journal of clinical investigation · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Giardia intestinalis is a common gastrointestinal protozoan worldwide, but its effects on childhood growth in developing countries are not clearly understood. The authors aimed to describe its effects on child growth. They followed 220 Peruvian children daily for diarrhea, weekly for stool samples, and monthly for anthropometry. The authors modeled the effect of nutritional status on the risk of Giardia infection and the risk of diarrhea attributable to Giardia using negative binomial regression. They modeled the effects of Giardia infection on growth using linear regression, with 85% of children becoming infected with Giardia and 87% of these becoming reinfected. In multivariable analysis, the risk of Giardia infection did not vary with weight for age (relative risk = 1.00, 95% confidence interval: 0.89, 1.12) or height for age (relative risk = 0.92, 95% confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval. The longitudinal prevalence of Giardia between 6 and 24 months of age was not associated with height gain in that interval (p = 0.981). Giardia was not associated with an increased risk of diarrhea at any age interval. Study results question the importance of Giardia as a childhood pathogen in developing countries where giardiasis is hyperendemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.