ArticleProceedings of the National Academy of Sciences of the United States of America2008
The molecular mechanism of lipid monolayer collapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 280 citations in OpenAlex.
- Self-stretching molecular monolayers with autonomous folding and mechanical adaptation.Science advances · 2026Article
- Experimental Observations of Graphene at Phospholipid Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Measuring the Equilibrium Spreading Pressure-A Tale of Three Amphiphiles.Molecules (Basel, Switzerland) · 2024Article
- The biophysical function of pulmonary surfactant.Biophysical journal · 2024Review
- Advantages of the classical thermodynamic analysis of single-and multi-component Langmuir monolayers from molecules of biomedical importance-theory and applications.Journal of the Royal Society, Interface · 2024Review
- AnSoft matter · 2023Article
- Dissipative Particle Dynamics Simulations for Shape Change of Growing Lipid Bilayer Vesicles.Life (Basel, Switzerland) · 2023Article
- Effect of Ester Moiety on Structural Properties of Binary Mixed Monolayers of Alpha-Tocopherol Derivatives with DPPC.Molecules (Basel, Switzerland) · 2022Article
- Biophysical properties of tear film lipid layer II. Polymorphism of FAHFA.Biophysical journal · 2022Article
- Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Competitive and/or cooperative interactions of graphene-family materials and benzo[a]pyrene with pulmonary surfactant: a computational and experimental study.Particle and fibre toxicology · 2021Article
- Interfacial behavior of phospholipid monolayers revealed by mesoscopic simulation.Biophysical journal · 2021Article
- Pulmonary route of administration is instrumental in developing therapeutic interventions against respiratory diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Review
- Understanding the Functional Properties of Lipid Heterogeneity in Pulmonary Surfactant Monolayers at the Atomistic Level.Frontiers in cell and developmental biology · 2020Article
- Adsorption of Phospholipids at the Air-Water Surface.Biophysical journal · 2019Article
- Review
- Phospholipid Chain Interactions with Cholesterol Drive Domain Formation in Lipid Membranes.Biophysical journal · 2018Article
- Lateral Non-covalent Clamping of Graphene at the Edges Using a Lipid Scaffold.ACS applied materials & interfaces · 2018Article
- Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids.Biomicrofluidics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid monolayers at an air-water interface can be compressed laterally and reach high surface density. Beyond a certain threshold, they become unstable and collapse. Lipid monolayer collapse plays an important role in the regulation of surface tension at the air-liquid interface in the lungs. Although the structures of lipid aggregates formed upon collapse can be characterized experimentally, the mechanism leading to these structures is not fully understood. We investigate the molecular mechanism of monolayer collapse using molecular dynamics simulations. Upon lateral compression, the collapse begins with buckling of the monolayer, followed by folding of the buckle into a bilayer in the water phase. Folding leads to an increase in the monolayer surface tension, which reaches the equilibrium spreading value. Immediately after their formation, the bilayer folds have a flat semielliptical shape, in agreement with theoretical predictions. The folds undergo further transformation and form either flat circular bilayers or vesicles. The transformation pathway depends on macroscopic parameters of the system: the bending modulus, the line tension at the monolayer-bilayer connection, and the line tension at the bilayer perimeter. These parameters are determined by the system composition and temperature. Coexistence of the monolayer with lipid aggregates is favorable at lower tensions of the monolayer-bilayer connection. Transformation into a vesicle reduces the energy of the fold perimeter and is facilitated for softer bilayers, e.g., those with a higher content of unsaturated lipids, or at higher temperatures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.