ArticleJournal of cellular physiology2008
Multiple Kv1.5 targeting to membrane surface microdomains.
Article in Journal of cellular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Palmitoylation of Voltage-Gated Ion Channels.International journal of molecular sciences · 2022Review
- S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2.1 subunit.Cellular and molecular life sciences : CMLS · 2022Article
- Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits.Frontiers in physiology · 2022Article
- KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology.Scientific reports · 2021Article
- Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections.Cell reports · 2020Article
- Regulation of interleukin-1 beta secretion from macrophages via modulation of potassium ion (KFEBS letters · 2019Article
- Caveolar targeting links Kv1.3 with the insulin-dependent adipocyte physiology.Cellular and molecular life sciences : CMLS · 2018Article
- Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.Scientific reports · 2017Article
- Caveolin interaction governs Kv1.3 lipid raft targeting.Scientific reports · 2016Article
- Tagging strategies strongly affect the fate of overexpressed caveolin-1.Traffic (Copenhagen, Denmark) · 2015Article
- Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection.Current pharmaceutical design · 2014Review
- A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes.PloS one · 2014Article
- Article
- Comparison of protein behavior between wild-type and G601S hERG in living cells by fluorescence correlation spectroscopy.The journal of physiological sciences : JPS · 2011Article
- Plasticity in membrane cholesterol contributes toward electrical maturation of hearing.The Journal of biological chemistry · 2011Article
- Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences.The Journal of general physiology · 2010Article
- Kv1.5 in the immune system: the good, the bad, or the ugly?Frontiers in physiology · 2010Article
- Voltage-dependent K(+)-channel responses during activation and damage in alveolar macrophages induced by quartz particles.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
- Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.Molecular biology of the cell · 2009Article
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Authors and funding
7 authors.
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Abstract
Surface expression of voltage-dependent K(+) channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules and their ion channel substrates. Kv1.3 associates with Kv1.5 to form functional channels in macrophages. Different isoform stoichiometries lead to distinct heteromeric channels which may be further modulated by targeting the complex to different membrane surface microdomains. Kv1.3 targets to lipid rafts, whereas Kv1.5 localization is under debate. With this in mind, we wanted to study whether heterotetrameric Kv1.5-containing channels target to lipid rafts. While in transfected HEK-293 cells, homo- and heterotetrameric channels targeted to rafts, Kv1.5 did not target to rafts in macrophages. Therefore, Kv1.3/Kv1.5 hybrid channels are mostly concentrated in non-raft microdomains. However, LPS-induced activation, which increases the Kv1.3/Kv1.5 ratio and caveolin, targeted Kv1.5 back to lipid rafts. Moreover, Kv1.5 did not localize to low-buoyancy fractions in L6E9 skeletal myoblasts, which also coexpress both channels, heart membranes or cardiomyocyes. Coexpression of a Cav3(DGV)-mutant confined Kv1.5 to Cav3(DGV)-vesicles of HEK cells. Contrarily, coexpression of Kvbeta2.1 impaired the Kv1.5 targeting to raft microdomains in HEK cells. Our results indicate that Kv1.5 partnership interactions are underlying mechanisms governing channel targeting to lipid rafts.
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