ArticleMolecular biology reports2009
Molecular characterization of Echinococcus granulosus of Indian animal isolates on the basis of nuclear and mitochondrial genotype.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Mitochondrial nad5 gene-based genetic diversity analysis of Echinococcus granulosus sensu lato hydatid cysts in small ruminants of north India.Molecular biology reports · 2026Article
- Phylogenetics and Pathology of Hydatid Disease in Slaughtered Buffaloes of North India.Acta parasitologica · 2021Article
- Prevalence and spatial distribution patterns of human echinococcosis at the township level in Sichuan Province, China.Infectious diseases of poverty · 2021Article
- Molecular and epidemiological updates on cystic echinococcosis infecting water buffaloes from Egypt.Veterinary world · 2016Article
- The molecular phylogenetic signature of Bali cattle revealed by maternal and paternal markers.Molecular biology reports · 2013Article
- Molecular characterization of Echinococcus granulosus cysts in north Indian patients: identification of G1, G3, G5 and G6 genotypes.PLoS neglected tropical diseases · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixty-six isolates of larval stage of Echinococcus granulosus, a known pathogenic parasite of man and animals were collected from cattle, buffalo, sheep, and goats. Single-stranded conformation polymorphism (SSCP) for analysis of variation after denaturation of amplicon of intron of actin II (ACTII) revealed six SSCP phenotypes. Intron portion was analyzed considering introns-early and introns-late theories. Isolates belonging to different conformers were further screened for mitochondrial ATPase subunit 6 (ATP6) and NADH dehydrogenase subunit II (nadII) genotypes. Assignment of each isolate to its specific strain was achieved after comparing with standard genotypes of E. granulosus. Variants deduced by nuclear targets did not match with mitochondrial haplotypes. A possible explanation for this observation can be attributed toward interspecific hybridization since cross-fertilization occurs less frequently in hermaphrodite organisms. A phylogenetic tree drawn on the basis of predicted aminoacid sequence of ATP6 and nadII revealed two distinct clusters i.e. E. granulosus sensu stricto and E. ortleppi/cattle strain (EG5). To the best of our knowledge, this is the first report of genetic characterization of two distinct ATP6 and nadII genotypes of zoonotic importance living in sympatry.
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