ArticleBulletin of mathematical biology2008
Growth based morphogenesis of vertebrate limb bud.
Article in Bulletin of mathematical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Mathematical modeling for developmental processes.Development, growth & differentiation · 2023Review
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- Quantification of cell behaviors and computational modeling show that cell directional behaviors drive zebrafish pectoral fin morphogenesis.Bioinformatics (Oxford, England) · 2021Article
- Self-sustained planar intercalations due to mechanosignaling feedbacks lead to robust axis extension during morphogenesis.Scientific reports · 2020Article
- Article
- Collective cell movement promotes synchronization of coupled genetic oscillators.Biophysical journal · 2014Article
- Digit patterning during limb development as a result of the BMP-receptor interaction.Scientific reports · 2012Article
- Study on multicellular systems using a phase field model.PloS one · 2012Article
- A computational clonal analysis of the developing mouse limb bud.PLoS computational biology · 2011Article
- Multi-cellular logistics of collective cell migration.PloS one · 2011Article
- Limbs made to measure.PLoS biology · 2010Article
- Article
- Article
- Wnt/planar cell polarity signaling: an important mechanism to coordinate growth and patterning in the limb.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many genes and their regulatory relationships are involved in developmental phenomena. However, by chemical information alone, we cannot fully understand changing organ morphologies through tissue growth because deformation and growth of the organ are essentially mechanical processes. Here, we develop a mathematical model to describe the change of organ morphologies through cell proliferation. Our basic idea is that the proper specification of localized volume source (e.g., cell proliferation) is able to guide organ morphogenesis, and that the specification is given by chemical gradients. We call this idea "growth-based morphogenesis." We find that this morphogenetic mechanism works if the tissue is elastic for small deformation and plastic for large deformation. To illustrate our concept, we study the development of vertebrate limb buds, in which a limb bud protrudes from a flat lateral plate and extends distally in a self-organized manner. We show how the proportion of limb bud shape depends on different parameters and also show the conditions needed for normal morphogenesis, which can explain abnormal morphology of some mutants. We believe that the ideas shown in the present paper are useful for the morphogenesis of other organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.