ReviewImmunologic research2008
Homeostatic control of B lymphocyte subsets.
Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring the Interplay between Cellular Senescence, Immunity, and Fibrosing Interstitial Lung Diseases: Challenges and Opportunities.International journal of molecular sciences · 2024Review
- Impaired B-cell function inFrontiers in immunology · 2024Article
- Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.Frontiers in immunology · 2021Article
- B cells in chronic graft-versus-host disease.Human immunology · 2019Review
- B Cell Development in the Bone Marrow Is Regulated by Homeostatic Feedback Exerted by Mature B Cells.Frontiers in immunology · 2016Article
- DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- APRIL mediates peritoneal B-1 cell homeostasis.Immunology letters · 2014Article
- New roles for the BLyS/BAFF family in antigen-experienced B cell niches.Cytokine & growth factor reviews · 2014Review
- BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.Cancer immunology, immunotherapy : CII · 2013Article
- Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells.Frontiers in immunology · 2013Article
- Targeting metabolism and autophagy in the context of haematologic malignancies.International journal of cell biology · 2012Article
- B cells and transplantation tolerance.Nature reviews. Nephrology · 2010Review
- B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.Transplantation reviews (Orlando, Fla.) · 2010Review
- Article
- B-cell tolerance in transplantation: is repertoire remodeling the answer?Expert review of clinical immunology · 2009Article
- Cracking the BAFF code.Nature reviews. Immunology · 2009Review
- Cell-autonomous role for NF-kappa B in immature bone marrow B cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Lymphocyte homeostasis poses a multi-faceted biological puzzle, because steady pre-immune populations must be maintained at an acceptable steady state to yield effective protection, despite stringent selective events during their generation. In addition, activated, memory and both short- and long-term effectors must be governed by independent homeostatic mechanisms. Finally, advancing age is accompanied by substantial changes that impact the dynamics and behavior of these pools, leading to cumulative homeostatic perturbations and compensation. Our laboratory has focused on the over-arching role of BLyS family ligands and receptors in these processes. These studies have led to a conceptual framework within which distinct homeostatic niches are specified by BLyS receptor signatures, which define the BLyS family ligands that can afford survival. The cues for establishing these receptor signatures, as well as the downstream survival mechanisms involved, are integrated with cell extrinsic inputs via cross talk among downstream mediators. A refined understanding of these relationships should yield insight into the selection and maintenance of B cell subsets, as well as an appreciation of how homeostatic mechanisms may contribute to immunosenescence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.