ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Diverse mechanisms underlie glycinergic feedback transmission onto rod bipolar cells in rat retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- Hexaraphane as a potential therapeutic strategy for tauopathies.Redox biology · 2026Article
- Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells.Biological research · 2025Article
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina.iScience · 2024Article
- EAAT5 Glutamate Transporter-Mediated Inhibition in the Vertebrate Retina.Frontiers in cellular neuroscience · 2021Review
- A17 Amacrine Cells and Olfactory Granule Cells: Parallel Processors of Early Sensory Information.Frontiers in cellular neuroscience · 2020Review
- Rod-cone crossover connectome of mammalian bipolar cells.The Journal of comparative neurology · 2019Article
- Synaptic inhibition tunes contrast computation in the retina.Visual neuroscience · 2019Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Low concentrations of ethanol but not of dimethyl sulfoxide (DMSO) impair reciprocal retinal signal transduction.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Complex inhibitory microcircuitry regulates retinal signaling near visual threshold.Journal of neurophysiology · 2015Article
- Different types of retinal inhibition have distinct neurotransmitter release properties.Journal of neurophysiology · 2015Article
- Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.Frontiers in cellular neuroscience · 2015Article
- Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.Journal of neurophysiology · 2013Article
- Inhibition to retinal rod bipolar cells is regulated by light levels.Journal of neurophysiology · 2013Article
- ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina.The Journal of comparative neurology · 2013Article
- Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Receptor targets of amacrine cells.Visual neuroscience · 2012Review
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2 authors.
Funding
Abstract
Synaptic inhibition shapes visual signaling in the inner retina, but the physiology of most amacrine cells, the interneurons that mediate this inhibition, is poorly understood. Discerning the function of most individual amacrine cell types is a daunting task, because few molecular or morphological markers specifically distinguish between approximately two dozen different amacrine cell types. Here, we examine a functional subset of amacrine cells by pharmacologically isolating glycinergic inhibition and evoking feedback IPSCs in a single cell type, the rod bipolar cell (RBC), with brief glutamate applications in the inner plexiform layer. We find that glycinergic amacrine cells innervating RBCs receive excitatory inputs from ON and OFF bipolar cells primarily via NMDA receptors (NMDARs) and Ca2+-impermeable AMPA-type glutamate receptors. Glycine release from amacrine cells is triggered by Ca2+ influx through both voltage-gated Ca2+ (Ca(v)) channels and NMDARs. These intracellular Ca2+signals are amplified by Ca2+-induced Ca2+ release via both ryanodine and IP3 receptors, which are activated independently by Ca2+ influx through Ca(v) channels and NMDARs, respectively. Glycinergic feedback signaling depends strongly, although not completely, on voltage-gated Na+ channels, and the spatial extent of feedback inhibition is expanded by gap junction connections between glycinergic amacrine cells. These results indicate that a diversity of mechanisms underlie glycinergic feedback inhibition onto RBCs, yet they highlight several physiological themes that appear to distinguish amacrine cell function.
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