ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Analog modulation of mossy fiber transmission is uncoupled from changes in presynaptic Ca2+.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.Cells · 2024Article
- Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- Fluorescence lifetime imaging reveals regulation of presynaptic CaJournal of neurochemistry · 2021Article
- Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study.Frontiers in cellular neuroscience · 2020Article
- Corrigendum: Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study.Frontiers in cellular neuroscience · 2020Article
- Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype.Biomaterials science · 2019Article
- Multiplex imaging relates quantal glutamate release to presynaptic CaNature communications · 2019Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Glutamate Imaging Reveals Multiple Sites of Stochastic Release in the CA3 Giant Mossy Fiber Boutons.Frontiers in cellular neuroscience · 2019Article
- Excitability Tuning of Axons by Afterdepolarization.Frontiers in cellular neuroscience · 2019Review
- Monitoring intracellular nanomolar calcium using fluorescence lifetime imaging.Nature protocols · 2018Article
- Axonal GABAThe Journal of physiology · 2017Article
- Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling.Nature communications · 2016Article
- Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels.Nature communications · 2015Article
- Neuronal adaptation involves rapid expansion of the action potential initiation site.Nature communications · 2014Article
- What are the mechanisms for analogue and digital signalling in the brain?Nature reviews. Neuroscience · 2013Review
- Monitoring local synaptic activity with astrocytic patch pipettes.Nature protocols · 2012Article
- Targeted axon-attached recording with fluorescent patch-clamp pipettes in brain slices.Nature protocols · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Subthreshold somatic depolarization has been shown recently to modulate presynaptic neurotransmitter release in cortical neurons. To understand the mechanisms underlying this mode of signaling in the axons of dentate granule cells (hippocampal mossy fibers), we have combined two-photon Ca2+ imaging with dual-patch recordings from somata and giant boutons forming synapses on CA3 pyramidal cells. In intact axons, subthreshold depolarization propagates both orthodromically and antidromically, with an estimated length constant of 200-600 microm depending on the signal waveform. Surprisingly, presynaptic depolarization sufficient to enhance glutamate release at mossy fiber-CA3 pyramidal cell synapses has no detectable effect on either basal Ca2+-dependent fluorescence or action-potential-evoked fluorescence transients in giant boutons. We further estimate that neurotransmitter release varies with presynaptic Ca2+ entry with a 2.5-power relationship and that depolarization-induced synaptic facilitation remains intact in the presence of high-affinity presynaptic Ca2+ buffers or after blockade of local Ca2+ stores. We conclude that depolarization-dependent modulation of transmission at these boutons does not rely on changes in presynaptic Ca2+.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.