ArticleJournal of neurophysiology2008
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory.Molecular psychiatry · 2022Article
- Atypical Expression and Activation of GluN2A- and GluN2B-Containing NMDA Receptors at Ganglion Cells during Retinal Degeneration.Neuroscience · 2018Article
- Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System.Molecular neurobiology · 2017Review
- Distribution and effects of the muscarinic receptor subtypes in the primary visual cortex.Frontiers in synaptic neuroscience · 2015Review
- LTP and LTD in the visual cortex require the activation of NOX2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Development and matching of binocular orientation preference in mouse V1.Frontiers in systems neuroscience · 2014Article
- A prominent role for triheteromeric GluN1/GluN2A/GluN2B NMDARs at central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.Cold Spring Harbor perspectives in medicine · 2013Review
- NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.Neuron · 2012Article
- GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of long-term plasticity induction by the channel and C-terminal domains of GluN2 subunits.Molecular neurobiology · 2011Review
- Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses.The Journal of biological chemistry · 2011Article
- Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.Developmental neurobiology · 2011Article
- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Nature reviews. Neuroscience · 2010Review
- NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling.Journal of neurochemistry · 2010Article
- Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- STDP in the Developing Sensory Neocortex.Frontiers in synaptic neuroscience · 2010Article
- The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The suggestion that NMDA receptor (NMDAR)-dependent plasticity is subunit specific, with NR2B-types required for long-term depression (LTD) and NR2A-types critical for the induction of long-term potentiation (LTP), has generated much attention and considerable debate. By investigating the suggested subunit-specific roles of NMDARs in the mouse primary visual cortex over development, we report several important findings that clarify the roles of NMDAR subtypes in synaptic plasticity. We observed that LTD was not attenuated by application of ifenprodil, an NR2B-type antagonist, or NVP-AAM007, a less selective NR2A-type antagonist. However, we were surprised that NVP-AAM007 completely blocked adult LTP (postnatal day (P) 45-90), while only modestly affecting juvenile LTP (P21-28). To assess whether this developmental transition reflected an increasing role for NR2A-type receptors with maturity, we characterized the specificity of NVP-AAM007. We found not only that NVP-AAM007 lacks discernable subunit specificity but also that the effects of NVP-AAM077 on LTP could be mimicked using subsaturating concentrations of APV, a global NMDAR antagonist. These results indicate that the effects of NVP-AAM077 on synaptic plasticity are largely explained by nonspecific blockade of NMDARs. Moreover our findings are the first to reveal a developmental increase in the sensitivity of LTP to NMDAR antagonism. We suggest that discrepant reports describing the effect of NVP-AAM077 on LTP may be partially explained by this developmental shift in the properties of LTP. These results indicate that the degree of NMDAR activation required for LTP increases with development, providing insight into a novel underlying mechanism governing the properties of synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.