ArticleJournal of neurophysiology2008
Synaptic ribbon enables temporal precision of hair cell afferent synapse by increasing the number of readily releasable vesicles: a modeling study.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023Review
- The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses.Frontiers in molecular neuroscience · 2021Article
- Quantitative FluorescentFrontiers in cellular neuroscience · 2021Article
- How to Build a Fast and Highly Sensitive Sound Detector That Remains Robust to Temperature Shifts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.eLife · 2018Article
- Synaptic reliability and temporal precision are achieved via high quantal content and effective replenishment: auditory brainstem versus hippocampus.The Journal of physiology · 2017Article
- Intensity-dependent timing and precision of startle response latency in larval zebrafish.The Journal of physiology · 2017Article
- RIM-Binding Protein 2 Promotes a Large Number of CaFrontiers in cellular neuroscience · 2017Article
- Synaptic studies inform the functional diversity of cochlear afferents.Hearing research · 2015Article
- Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.The EMBO journal · 2015Article
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapse.Neuron · 2014Article
- Specialized postsynaptic morphology enhances neurotransmitter dilution and high-frequency signaling at an auditory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mechanism study of laser cochleostomy-induced early hearing loss in a rat model.Lasers in medical science · 2014Article
- Article
- Mitochondria toxin-induced acute cochlear cell death indicates cellular activity-correlated energy consumption.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic ribbons are classically associated with mediating indefatigable neurotransmitter release by sensory neurons that encode persistent stimuli. Yet when hair cells lack anchored ribbons, the temporal precision of vesicle fusion and auditory nerve discharges are degraded. A rarified statistical model predicted increasing precision of first-exocytosis latency with the number of readily releasable vesicles. We developed an experimentally constrained biophysical model to test the hypothesis that ribbons enable temporally precise exocytosis by increasing the readily releasable pool size. Simulations of calcium influx, buffered calcium diffusion, and synaptic vesicle exocytosis were stochastic (Monte Carlo) and yielded spatiotemporal distributions of vesicle fusion consistent with experimental measurements of exocytosis magnitude and first-spike latency of nerve fibers. No single vesicle could drive the auditory nerve with requisite precision, indicating a requirement for multiple readily releasable vesicles. However, plasmalemma-docked vesicles alone did not account for the nerve's precision--the synaptic ribbon was required to retain a pool of readily releasable vesicles sufficiently large to statistically ensure first-exocytosis latency was both short and reproducible. The model predicted that at least 16 readily releasable vesicles were necessary to match the nerve's precision and provided insight into interspecies differences in synaptic anatomy and physiology. We confirmed that ribbon-associated vesicles were required in disparate calcium buffer conditions, irrespective of the number of vesicles required to trigger an action potential. We conclude that one of the simplest functions ascribable to the ribbon--the ability to hold docked vesicles at an active zone--accounts for the synapse's temporal precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.