ArticleMolecular biology of the cell2008
Prominent actin fiber arrays in Drosophila tendon cells represent architectural elements different from stress fibers.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The Entomotoxic Fungal LectinJournal of agricultural and food chemistry · 2026Article
- Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces.Journal of cell science · 2025Article
- Developmental origin of tendon diversity inFrontiers in physiology · 2023Review
- Chitin deacetylases are necessary for insect femur muscle attachment and mobility.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance.Developmental neurobiology · 2022Article
- Development of the indirect flight muscles of Aedes aegypti, a main arbovirus vector.BMC developmental biology · 2021Article
- An insight on Drosophila myogenesis and its assessment techniques.Molecular biology reports · 2020Review
- Insect Cuticular Chitin Contributes to Form and Function.Current pharmaceutical design · 2020Article
- Spectraplakin family proteins - cytoskeletal crosslinkers with versatile roles.Journal of cell science · 2017Review
- Periodic actin structures in neuronal axons are required to maintain microtubules.Molecular biology of the cell · 2017Article
- Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development.Frontiers in cell and developmental biology · 2017Review
- Article
- Establishment of the Muscle-Tendon Junction During Thorax Morphogenesis in Drosophila Requires the Rho-Kinase.Genetics · 2016Article
- The (dys)functional extracellular matrix.Biochimica et biophysica acta · 2015Review
- Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model.PloS one · 2011Article
- Intertissue mechanical stress affects Frizzled-mediated planar cell polarity in the Drosophila notum epidermis.Current biology : CB · 2011Article
- In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Tendon cells are specialized cells of the insect epidermis that connect basally attached muscle tips to the cuticle on their apical surface via prominent arrays of microtubules. Tendon cells of Drosophila have become a useful genetic model system to address questions with relevance to cell and developmental biology. Here, we use light, confocal, and electron microscopy to present a refined model of the subcellular organization of tendon cells. We show that prominent arrays of F-actin exist in tendon cells that fully overlap with the microtubule arrays, and that type II myosin accumulates in the same area. The F-actin arrays in tendon cells seem to represent a new kind of actin structure, clearly distinct from stress fibers. They are highly resistant to F-actin-destabilizing drugs, to the application of myosin blockers, and to loss of integrin, Rho1, or mechanical force. They seem to represent an important architectural element of tendon cells, because they maintain a connection between apical and basal surfaces even when microtubule arrays of tendon cells are dysfunctional. Features reported here and elsewhere for tendon cells are reminiscent of the structural and molecular features of support cells in the inner ear of vertebrates, and they might have potential translational value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.