Evidence map›Paper›PMID 18667430›Full record

ArticleThe Journal of biological chemistry2008

Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.

Anna J Jasiak, Holger Hartmann, Elena Karakasili, Marian Kalocsay, Andrew Flatley, Elisabeth Kremmer, Katja Strässer, Dietmar E Martin, Johannes Söding, Patrick Cramer

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. ImprovingBiotechnology for biofuels · 2017
    Article
  3. Article
  4. Coupling mRNA synthesis and decay.Molecular and cellular biology · 2014
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Archaeal RNA polymerase.Current opinion in structural biology · 2009
    Review
  18. Article
  19. Article
  20. Modulation of RNA polymerase II subunit composition by ubiquitylation.Proceedings of the National Academy of Sciences of the United States of America · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna J JasiakGene Center and Center for Integrated Protein Science Munich CIPSM, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University of Munich, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany.
Holger Hartmann
Elena Karakasili
Marian Kalocsay
Andrew Flatley
Elisabeth Kremmer
Katja Strässer
Dietmar E Martin
Johannes Söding
Patrick Cramer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeast RNA polymerase (Pol) II consists of a 10-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immunoprecipitation coupled to high resolution tiling microarray analysis. We show that the genome-wide occupancy profiles for Rpb7 and the core subunit Rpb3 are essentially identical. Thus, the complete Pol II associates with DNA in vivo, consistent with functional roles of Rpb4/7 throughout the transcription cycle.

Indexed as

Genome, FungalRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticRNA Polymerase IISaccharomyces cerevisiae Proteins

Identifiers

PMID18667430
PMCPMC3258907

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.