ArticleFungal genetics and biology : FG & B2008
Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus.
Article in Fungal genetics and biology : FG & B, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 203 citations in OpenAlex.
- Article
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- Chemical Investigation of the Global RegulatorMarine drugs · 2026Article
- The global regulator LaeA controls expression of genes involved in diverse primary and secondary metabolites biosynthesis and their secretion in fungi.Frontiers in microbiology · 2026Review
- Distinction BetweenJournal of fungi (Basel, Switzerland) · 2025Article
- ZfpA-Dependent Quorum Sensing Shifts in Morphology and Secondary Metabolism in Aspergillus flavus.Environmental microbiology · 2025Article
- Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis.Applied and environmental microbiology · 2024Review
- Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites.Journal of fungi (Basel, Switzerland) · 2024Review
- The GeneToxins · 2024Article
- An environmental isolate ofFrontiers in microbiology · 2024Article
- The Temporal Dynamics of Sensitivity, Aflatoxin Production, and Oxidative Stress ofFoods (Basel, Switzerland) · 2023Article
- Light regulation of secondary metabolism in fungi.Journal of biological engineering · 2023Review
- Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis.Science China. Life sciences · 2023Article
- Molecular regulation of fungal secondary metabolism.World journal of microbiology & biotechnology · 2023Review
- Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress.Heliyon · 2023Article
- Are CurrentMycobiology · 2023Article
- Review
- Itaconic acid production is regulated by LaeA inMetabolic engineering communications · 2022Article
- LaeA regulates morphological development and ochratoxin A biosynthesis in Aspergillus niger.Mycotoxin research · 2022Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The nuclear regulator LaeA has been shown to govern production of multiple secondary metabolites in Aspergillus nidulans and Aspergillus fumigatus. Herein we examine the role of this protein in Aspergillus flavus. Similarly as in other Aspergilli, LaeA had a major effect on A. flavus secondary metabolism where DeltalaeA and over-expression laeA (OE::laeA) strains yielded opposite phenotypes resulting in decreased (increased) secondary metabolite production. The two mutant strains also exhibited striking morphological phenotypes in the loss (increase) of sclerotial production in comparison to wildtype. Growth on seed was marked by decreased (increased) conidial and aflatoxin production of the respective mutants; this was accompanied by decreased lipase activity in DeltalaeA, an enzymatic process correlated with seed maceration. Transcriptional examination of the mutants showed LaeA negatively regulates expression of its recently identified nuclear partner VeA, another global regulator of A. flavus secondary metabolites and sclerotia.
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