ArticleJournal of natural products2008
Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.
Article in Journal of natural products, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023.Marine drugs · 2025Review
- Targeted Isolation ofACS omega · 2023Article
- Saquayamycin BMarine drugs · 2022Article
- Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal DerivedMicroorganisms · 2020Article
- Mzabimycins A and B, novel intracellular angucycline antibiotics produced bySaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-DerivedMarine drugs · 2019Article
- Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.The Journal of antibiotics · 2018Article
- Stress-Driven Discovery of New Angucycline-Type Antibiotics from a MarineMarine drugs · 2018Article
- Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490.The Journal of antibiotics · 2017Article
- Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Natural product reports · 2017Review
- A comprehensive review of glycosylated bacterial natural products.Chemical Society reviews · 2015Review
- Monacyclinones, New Angucyclinone Metabolites Isolated from Streptomyces sp. M7_15 Associated with the Puerto Rican Sponge Scopalina ruetzleri.Marine drugs · 2015Article
- Cytotoxic and antibacterial angucycline- and prodigiosin-analogues from the deep-sea derived Streptomyces sp. SCSIO 11594.Marine drugs · 2015Article
- Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.The Journal of antibiotics · 2014Article
- Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.Journal of natural products · 2013Article
- Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15.Journal of natural products · 2013Article
- Evaluation of bioactive compounds produced by Nocardia levis MK-VL_113 & Streptomyces tendae TK-VL_333 for cytotoxic activity.The Indian journal of medical research · 2013Article
- Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1.The Journal of antibiotics · 2012Article
- Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.Journal of natural products · 2012Article
- Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.Natural product reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.