ArticleWorld journal of gastroenterology2008
Univariate and multivariate analysis of risk factors for severe Clostridium difficile-associated diarrhoea: importance of co-morbidity and serum C-reactive protein.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association Between Immunosuppressive Therapy and Outcome of Clostridioides difficile Infection: Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2022Pooled it
- Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review.PloS one · 2014Pooled it
- Article
- Article
- Early Prognostic Stratification ofJournal of personalized medicine · 2022Article
- Treatment and Outcomes ofJournal of clinical medicine · 2022Article
- Usual opioid dosing does not adversely affect the course of healthcare-associatedPain management · 2021Article
- Pet Ownership Protects Against Recurrence ofOpen forum infectious diseases · 2020Article
- Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore.Scientific reports · 2019Article
- Colon Surgery Risk With Corticosteroids Versus Immunomodulators or Biologics in Inflammatory Bowel Disease Patients With Clostridium difficile Infection.Inflammatory bowel diseases · 2019Article
- Proton pump inhibitors and 180-day mortality in the elderly afterGut pathogens · 2019Article
- Clostridium difficile infection in hospitalized patients with inflammatory bowel disease: Prevalence, risk factors, and prognosis.Medicine · 2018Observational
- Prevalence of Clostridium difficile infection and colonization in a tertiary hospital and elderly community of North-Eastern Peninsular Malaysia.Epidemiology and infection · 2017Article
- The efficacy of fidaxomicin in the treatment of Clostridium difficile infection in a real-world clinical setting: a Spanish multi-centre retrospective cohort.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- [Clostridium difficile infections in geriatric patients].Zeitschrift fur Gerontologie und Geriatrie · 2016Review
- A Comparison of Current Guidelines of Five International Societies on Clostridium difficile Infection Management.Infectious diseases and therapy · 2016Review
- Article
- Clostridium Difficile Infection from a Surgical Perspective.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care.World journal of gastroenterology · 2013Article
- Increased hospital length of stay attributable to Clostridium difficile infection in patients with four co-morbidities: an analysis of hospital episode statistics in four European countries.The European journal of health economics : HEPAC : health economics in prevention and care · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.
methodsWe analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
resultsSevere CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P < 0.001) were independent predictors of severe CDAD.
conclusionPatients with a severe level of co-morbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.