An effective strategy for the design of proteins with enhanced mechanical stability.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level.Nature communications · 2019
   Article
2. Effects of ligand binding on the mechanical stability of protein GB1 studied by steered molecular dynamics simulation.Journal of molecular modeling · 2016
   Article
3. Engineering proteins with enhanced mechanical stability by force-specific sequence motifs.Proteins · 2012
   Article
4. Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins.Nature · 2011
   Article
5. Enhancing the mechanical stability of proteins through a cocktail approach.Biophysical journal · 2011
   Article
6. Computational and single-molecule force studies of a macro domain protein reveal a key molecular determinant for mechanical stability.Proceedings of the National Academy of Sciences of the United States of America · 2010
   Article
7. Understanding biology by stretching proteins: recent progress.Current opinion in structural biology · 2010
   Review
8. Non-native interactions are critical for mechanical strength in PKD domains.Structure (London, England : 1993) · 2009
   Article
9. Identification of a mechanical rheostat in the hydrophobic core of protein L.Journal of molecular biology · 2009
   Article
10. On the remarkable mechanostability of scaffoldins and the mechanical clamp motif.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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