ArticleBritish journal of haematology2008
Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency.
Article in British journal of haematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- HRI protein kinase in cytoplasmic heme sensing and mitochondrial stress response: Relevance to hematological and mitochondrial diseases.The Journal of biological chemistry · 2025Review
- The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease.Frontiers in microbiology · 2024Article
- Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells.Experimental hematology · 2023Article
- The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance.Haematologica · 2021Review
- Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development.Cancers · 2021Review
- Review
- HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis.eLife · 2019Article
- Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.Science (New York, N.Y.) · 2018Article
- RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis.Frontiers in physiology · 2018Review
- Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.Haematologica · 2017Article
- Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver.Experimental hematology · 2015Article
- Translational control by heme-regulated eIF2α kinase during erythropoiesis.Current opinion in hematology · 2014Review
- The eIF2α kinases: their structures and functions.Cellular and molecular life sciences : CMLS · 2013Review
- Stressing HbF synthesis: role of translation?Blood · 2013Article
- Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages.Nanoscale research letters · 2013Article
- Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries.Pathogens and global health · 2012Review
- Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.Blood · 2012Article
- Iron metabolism: interactions with normal and disordered erythropoiesis.Cold Spring Harbor perspectives in medicine · 2012Review
- Conformational transitions of the catalytic domain of heme-regulated eukaryotic initiation factor 2α kinase, a key translational regulatory molecule.Journal of fluorescence · 2012Article
- Heme controls the regulation of protein tyrosine kinases Jak2 and Src.Biochemical and biophysical research communications · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Haem-regulated eIF2alpha kinase (HRI) is essential for the regulation of globin gene translation and the survival of erythroid precursors in iron/haem deficiency. This study found that that in iron deficiency, fetal definitive erythropoiesis is inhibited at the basophilic erythroblast stage with increased proliferation and elevated apoptosis. This hallmark of ineffective erythropoiesis is more severe in HRI deficiency. Microarray gene profiling analysis showed that HRI was required for adaptive gene expression in erythroid precursors during chronic iron deficiency. The number of genes with expression affected more than twofold increased, from 213 in iron deficiency and 73 in HRI deficiency, to 3135 in combined iron and HRI deficiencies. Many of these genes are regulated by Gata1 and Fog1. We demonstrate for the first time that Gata1 expression in developing erythroid precursors is decreased in iron deficiency, and is decreased further in combined iron and HRI deficiencies. Additionally, Fog1 expression is decreased in combined deficiencies, but not in iron or HRI deficiency alone. Our results indicate that HRI confers adaptive gene expression in developing erythroblasts during iron deficiency through maintaining Gata1/Fog1 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.