ArticleJournal of proteome research2008
The knowledge-integrated network biomarkers discovery for major adverse cardiac events.
Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
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- Early warning and diagnosis of liver cancer based on dynamic network biomarker and deep learning.Computational and structural biotechnology journal · 2023Article
- Detect the early-warning signals of diseases based on signaling pathway perturbations on a single sample.BMC bioinformatics · 2022Article
- Data analysis methods for defining biomarkers from omics data.Analytical and bioanalytical chemistry · 2022Review
- Transcriptional progressive patterns from mild to severe renal ischemia/reperfusion-induced kidney injury in mice.Frontiers in genetics · 2022Article
- Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022Review
- Network module identification-A widespread theoretical bias and best practices.Methods (San Diego, Calif.) · 2018Article
- Detecting Early Warning Signal of Influenza A Disease Using Sample-Specific Dynamical Network Biomarkers.BioMed research international · 2018Article
- Forecasting influenza A pandemic outbreak using protein dynamical network biomarkers.BMC systems biology · 2017Article
- iCAVE: an open source tool for visualizing biomolecular networks in 3D, stereoscopic 3D and immersive 3D.GigaScience · 2017Article
- Detecting early-warning signals for influenza A pandemic based on protein dynamical network biomarkers.Saudi journal of biological sciences · 2017Article
- Identifying module biomarker in type 2 diabetes mellitus by discriminative area of functional activity.BMC bioinformatics · 2015Article
- Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers.Journal of cellular and molecular medicine · 2015Review
- Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses.PloS one · 2015Article
- Network biology in medicine and beyond.Circulation. Cardiovascular genetics · 2014Article
- Survey of network-based approaches to research of cardiovascular diseases.BioMed research international · 2014Review
- Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects.Frontiers in cell and developmental biology · 2014Article
- Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases.Clinical and translational medicine · 2014Review
- Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.Cancer research · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The mass spectrometry (MS) technology in clinical proteomics is very promising for discovery of new biomarkers for diseases management. To overcome the obstacles of data noises in MS analysis, we proposed a new approach of knowledge-integrated biomarker discovery using data from Major Adverse Cardiac Events (MACE) patients. We first built up a cardiovascular-related network based on protein information coming from protein annotations in Uniprot, protein-protein interaction (PPI), and signal transduction database. Distinct from the previous machine learning methods in MS data processing, we then used statistical methods to discover biomarkers in cardiovascular-related network. Through the tradeoff between known protein information and data noises in mass spectrometry data, we finally could firmly identify those high-confident biomarkers. Most importantly, aided by protein-protein interaction network, that is, cardiovascular-related network, we proposed a new type of biomarkers, that is, network biomarkers, composed of a set of proteins and the interactions among them. The candidate network biomarkers can classify the two groups of patients more accurately than current single ones without consideration of biological molecular interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.