ReviewInternational urology and nephrology2009
Insulin: a novel agent in the pathogenesis of prostate cancer.
Review in International urology and nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Body mass index is associated with higher Gleason score and biochemical recurrence risk following radical prostatectomy in Chinese men: a retrospective cohort study and meta-analysis.World journal of surgical oncology · 2015Pooled it
- Pooled it
- An In-Depth Look Into the Epidemiological and Etiological Aspects of Prostate Cancer: A Literature Review.Cureus · 2023Review
- Association between obesity and frequency of high-grade prostate cancer on biopsy in men: A single-center retrospective study.Molecular and clinical oncology · 2022Article
- Article
- Association of Anthropometric Measures With the Risk of Prostate Cancer in the Multiethnic Cohort.American journal of epidemiology · 2021Article
- Review
- Abdominal obesity and prostate cancer risk: epidemiological evidence from the EPICAP study.Oncotarget · 2018Article
- Higher body mass index increases the risk for biopsy-mediated detection of prostate cancer in Chinese men.PloS one · 2015Article
- Association Between Average Daily Television Viewing Time and Chronic Obstructive Pulmonary Disease-Related Mortality: Findings From the Japan Collaborative Cohort Study.Journal of epidemiology · 2015Article
- Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification.BMC bioinformatics · 2012Article
- Dietary glycemic index, glycemic load, insulin index, fiber and whole-grain intake in relation to risk of prostate cancer.Cancer causes & control : CCC · 2011Article
- Association between C-peptide concentration and prostate cancer incidence in the CLUE II cohort study.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Prostate cancer cell proliferation and angiogenesis in different obese mice models.International journal of experimental pathology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer, the most frequent non-cutaneous malignancy in aging men, is a growing medical problem, representing the second leading cause of male cancer deaths. Despite its high morbidity, the etiology of prostate cancer remains largely unknown. Several studies have documented hormonal imbalance, such as alteration in androgens and estrogens, obesity, family history and growth factors, as risk factors in the pathogenesis of prostate cancer. Insulin is a growth-promoting hormone that is reported to be involved in the pathogenesis of various malignancies, such as breast and bladder cancers. Insulin is known to increase cancer risk through its effect on cell proliferation, differentiation and apoptosis. In the last decade, converging evidence from epidemiological and clinical studies suggests that the insulin is involved in the tumorigenesis and neoplastic growth of the prostate. Several mechanisms have been suggested to explain the possible causal relationship between insulin and prostate cancer, such as the sympathoexcitatory effect of insulin, alteration of sex hormone metabolism, insulin-like growth factor pathway, signal transduction mechanism and dyslipidemia. The present paper reviews relevant existing studies related to the role of insulin in the pathogenesis of prostate carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.