ReviewStem cell reviews2008
The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles.
Review in Stem cell reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Fractionated Infusion of Hematopoietic Progenitor Cells Does Not Improve Neutrophil Recovery or Survival in Allograft Recipients.Transplantation and cellular therapy · 2021Trial
- Exosome-Encapsulated miR-31, miR-192, and miR-375 Serve as Clinical Biomarkers of Gastric Cancer.Journal of oncology · 2023Article
- Activated polymorphonuclear derived extracellular vesicles are potential biomarkers of periprosthetic joint infection.PloS one · 2022Article
- An Overview of Current Research on Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Bibliometric Analysis From 2009 to 2021.Frontiers in bioengineering and biotechnology · 2022Article
- MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.Aging and disease · 2021Article
- Extracellular Vesicles in the Development of Cancer Therapeutics.International journal of molecular sciences · 2020Review
- Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells.Genes & diseases · 2020Article
- Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury.Stem cell research & therapy · 2019Review
- Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications.Pharmacology & therapeutics · 2018Review
- Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells.Stem cell reviews and reports · 2018Article
- Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins.Scientific reports · 2018Article
- Current Perspectives on Role of MSC in Renal Pathophysiology.Frontiers in physiology · 2018Review
- Extracellular Vesicles Released by Oxidatively Injured or Intact C2C12 Myotubes Promote Distinct Responses Converging toward Myogenesis.International journal of molecular sciences · 2017Article
- Biology and biogenesis of shed microvesicles.Small GTPases · 2017Review
- Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer.Cancer gene therapy · 2017Review
- Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells.Scientific reports · 2016Article
- Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases.Stem cell research & therapy · 2016Review
- Extracellular vesicles derived from mesenchymal stromal cells: a therapeutic option in respiratory diseases?Stem cell research & therapy · 2016Review
- Circulating miRNAs as biomarkers for endocrine disorders.Journal of endocrinological investigation · 2016Review
- Biological properties of extracellular vesicles and their physiological functions.Journal of extracellular vesicles · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Marrow stem cell regulation represents a complex and flexible system. It has been assumed that the system was intrinsically hierarchical in nature, but recent data has indicated that at the progenitor/stem cell level the system may represent a continuum with reversible alterations in phenotype occurring as the stem cells transit cell cycle. Short and long-term engraftment, in vivo and in vitro differentiation, gene expression, and progenitor numbers have all been found to vary reversibly with cell cycle. In essence, the stem cells appear to show variable potential, probably based on transcription factor access, as they proceed through cell cycle. Another critical component of the stem cell regulation is the microenvironment, so-called niches. We propose that there are not just several unique niche cells, but a wide variety of niche cells which continually change phenotype to appropriately interact with the continuum of stem cell phenotypes. A third component of the regulatory system is microvesicle transfer of genetic information between cells. We have shown that marrow cells can express the genetic phenotype of pulmonary epithelial cells after microvesicle transfer from lung to marrow cells. Similar transfers of tissue specific mRNA occur between liver, brain, and heart to marrow cells. Thus, there would appear to be a continuous genetic modulation of cells through microvesicle transfer between cells. We propose that there is an interactive triangulated Venn diagram with continuously changing stem cells interacting with continuously changing areas of influence, both being modulated by transfer of genetic information by microvesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.