Evidence map›Paper›PMID 18665245›Full record

ArticleThe open clinical cancer journal2008

Epithelial ovarian cancer: the role of cell cycle genes in the different histotypes.

Giuseppina D'Andrilli, Antonio Giordano, Alessandro Bovicelli

Abstract read
In one paragraph

Article in The open clinical cancer journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  7. Article
  8. Survival prediction based on inherited gene variation analysis.Methods in molecular biology (Clifton, N.J.) · 2013
    Article
  9. Review
  10. Article
  11. Article
  12. Inherited determinants of ovarian cancer survival.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giuseppina D'AndrilliSbarro Institute for Cancer Research and Molecular Medicine, Dept. of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Antonio Giordano
Alessandro Bovicelli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is frequently considered to be a disease of the cell cycle; alterations in different families of cell cycle regulators cooperate in tumor development. Molecular analysis of human tumors has shown that cell cycle regulators are frequently mutated in human neoplasms, which underscores how important the maintenance of cell cycle commitment is in the prevention of human cancer. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes which display a range of abnormalities with potential usefulness as markers of evolution or treatment response in epithelial ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to focus our attention on the genes involved in the development of tumors arising from the ovarian epithelium, which are the most common types of ovarian malignancies.

Indexed as

cancer therapyCell cycle deregulationovarian carcinoma histotypesovarian malignancy

Identifiers

PMID18665245
PMCPMC2490600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.