ArticlePloS one2008
The PlcR virulence regulon of Bacillus cereus.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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151 citing papers in PubMed, 328 citations in OpenAlex.
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- Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.Scientific reports · 2025Article
- Gene Detection and Enzymatic Activity of PsychrotrophicMicroorganisms · 2025Article
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- NupR Is Involved in the Control of PlcR: A Pleiotropic Regulator of Extracellular Virulence Factors.Microorganisms · 2025Article
- A taste of one's own medicine:Frontiers in immunology · 2025Article
- Gene expression dynamics inFrontiers in microbiology · 2025Article
- Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness ofbioRxiv : the preprint server for biology · 2024Article
- Investigating the Role of OrbF in Biofilm Biosynthesis and Regulation of Biofilm-Associated Genes inFoods (Basel, Switzerland) · 2024Article
- Genomic analysis and assessment of pathogenic (toxicogenic) potential of Staphylococcus haemolyticus and Bacillus paranthracis consortia isolated from bovine mastitis in Russia.Scientific reports · 2023Article
- Major distinctions between the two oligopeptide permease systems ofMicrobiology (Reading, England) · 2023Article
- The quorum-sensing peptidic inhibitor rescues host immune system eradication: A novel infectivity mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.FEMS microbiology reviews · 2023Review
- Bacillus cereus extracellular vesicles act as shuttles for biologically active multicomponent enterotoxins.Cell communication and signaling : CCS · 2023Article
- Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections.Peptide science (Hoboken, N.J.) · 2023Article
- Lactoferrin-based food supplements trigger toxin production of enteropathogenicFrontiers in microbiology · 2023Article
- From cereus to anthrax and back again: Assessment of the temperature-dependent phenotypic switching in the "cross-over" strainFrontiers in microbiology · 2023Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PlcR is a Bacillus cereus transcriptional regulator, which activates gene expression by binding to a nucleotidic sequence called the 'PlcR box'. To build a list of all genes included in the PlcR regulon, a consensus sequence was identified by directed mutagenesis. The reference strain ATCC14579 sequenced genome was searched for occurrences of this consensus sequence to produce a virtual regulon. PlcR control of these genes was confirmed by comparing gene expression in the reference strain and its isogenic Delta-plcR strain using DNA microarrays, lacZ fusions and proteomics methods. The resulting list included 45 genes controlled by 28 PlcR boxes. Forty of the PlcR controlled proteins were exported, of which 22 were secreted in the extracellular medium and 18 were bound or attached to cell wall structures (membrane or peptidoglycan layer). The functions of these proteins were related to food supply (phospholipases, proteases, toxins), cell protection (bacteriocins, toxins, transporters, cell wall biogenesis) and environment-sensing (two-component sensors, chemotaxis proteins, GGDEF family regulators). Four genes coded for cytoplasmic regulators. The PlcR regulon appears to integrate a large range of environmental signals, including food deprivation and self cell-density, and regulate the transcription of genes designed to overcome obstacles that hinder B. cereus growth within the host: food supply, host barriers, host immune defenses, and competition with other bacterial species. PlcR appears to be a key component in the efficient adaptation of B. cereus to its host environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.