ArticleBritish journal of cancer2008
[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- The therapeutic effect of a novel GAPDH inhibitor in mouse model of breast cancer and efficacy monitoring by molecular imaging.Cancer cell international · 2024Article
- Modulation of FDG Uptake by Cell Cycle Synchronization Using a T-Type Calcium Channel Inhibitor.Cancers · 2023Article
- Prospective comparison of early interimBMC cancer · 2021Article
- Synthesis of [Molecules (Basel, Switzerland) · 2020Article
- Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging.Oncotarget · 2017Article
- Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft.EJNMMI research · 2016Article
- Single-Cell Characterization of 18F-FLT Uptake with Radioluminescence Microscopy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Article
- Assessment of tumor response to chemotherapy in patients with breast cancer using (18)F-FLT: a meta-analysis.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer.British journal of cancer · 2014Article
- Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma.Translational respiratory medicine · 2013Review
- Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging.Cancer & metabolism · 2013Article
- The effects of 5-fluoruracil treatment on 3'-fluoro-3'-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells.Nuclear medicine and biology · 2012Article
- Early assessment of tumor response to JAC106, an anti-tubulin agent, by 3'-deoxy-3'-[¹⁸F]fluorothymidine in preclinical tumor models.European journal of nuclear medicine and molecular imaging · 2011Article
- Monitoring of tumor growth and post-irradiation recurrence in a diffuse intrinsic pontine glioma mouse model.Brain pathology (Zurich, Switzerland) · 2011Article
- Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography.Molecular imaging and biology · 2011Article
- Current molecular imaging positron emitting radiotracers in oncology.Nuclear medicine and molecular imaging · 2011Review
- Early detection of tumor response by FLT/microPET Imaging in a C26 murine colon carcinoma solid tumor animal model.Journal of biomedicine & biotechnology · 2011Article
- Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer.Cancer science · 2010Article
- Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2009Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased 2'-deoxy-2'-[18F]fluoro-D-glucose (FDG) uptake is the most commonly used marker for positron emission tomography in oncology. However, a proliferation tracer such as 3'-deoxy-3'-[18F]fluorothymidine (FLT) might be more specific for cancer. 3'-deoxy-3'-[18F]fluorothymidine uptake is dependent on thymidine kinase 1 (TK) activity, but the effects of chemotherapeutic agents are unknown. The aim of this study was to characterise FDG and FLT uptake mechanisms in vitro before and after exposure to chemotherapeutic agents. The effects of 5-fluorouracil (5-FU), doxorubicin and paclitaxel on FDG and FLT uptake were measured in MDA MB231 human breast cancer cells in relation to cell cycle distribution, expression and enzyme activity of TK-1. At IC50 concentrations, 5-FU resulted in accumulation in the G1 phase, but doxorubicin and paclitaxel induced a G2/M accumulation. Compared with untreated cells, 5-FU and doxorubicin increased TK-1 levels by >300. At 72 h, 5-FU decreased FDG uptake by 50% and FLT uptake by 54%, whereas doxorubicin increased FDG and FLT uptake by 71 and 173%, respectively. Paclitaxel increased FDG uptake with >100% after 48 h, whereas FLT uptake hardly changed. In conclusion, various chemotherapeutic agents, commonly used in the treatment of breast cancer, have different effects on the time course of uptake of both FDG and FLT in vitro. This might have implications for interpretation of clinical findings.
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