ReviewEndocrine reviews2008
Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.
Review in Endocrine reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Redefining β-Cell Function in Type 2 Diabetes Mellitus: From Comprehensive Assessment to Precision Medicine.Diabetes & metabolism journal · 2026Review
- Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes.Frontiers in endocrinology · 2023Review
- Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Alpha-1 antitrypsin suppresses macrophage activation and promotes islet graft survival after intrahepatic islet transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation.Frontiers in immunology · 2021Article
- The Flaws and Future of Islet Volume Measurements.Cell transplantation · 2018Review
- Article
- Residual β-Cell Function Predicts Clinical Response After Autologous Hematopoietic Stem Cell Transplantation.Stem cells translational medicine · 2016Article
- Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice.Gene therapy · 2015Article
- Human α1-antitrypsin modifies B-lymphocyte responses during allograft transplantation.Immunology · 2013Article
- Use of glucagon-like peptide-1 agonists to improve islet graft performance.Current diabetes reports · 2013Review
- Stem cell therapy to cure type 1 diabetes: from hype to hope.Stem cells translational medicine · 2013Review
- The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.Current diabetes reviews · 2012Article
- Naturally occurring immunoglobulin M (nIgM) autoantibodies prevent autoimmune diabetes and mitigate inflammation after transplantation.Annals of surgery · 2012Article
- Regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes.Current opinion in endocrinology, diabetes, and obesity · 2012Review
- Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- TNF-α acutely upregulates amylin expression in murine pancreatic beta cells.Diabetologia · 2011Article
- Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation.Journal of transplantation · 2011Article
- Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.Journal of transplantation · 2011Article
- Creating transplant tolerance by taming adverse intragraft innate immunity.F1000 biology reports · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Although type 1 diabetes cannot be prevented or reversed, replacement of insulin production by transplantation of the pancreas or pancreatic islets represents a definitive solution. At present, transplantation can restore euglycemia, but this restoration is short-lived, requires islets from multiple donors, and necessitates lifelong immunosuppression. An emerging paradigm in transplantation and autoimmunity indicates that systemic inflammation contributes to tissue injury while disrupting immune tolerance. We identify multiple barriers to successful islet transplantation, each of which either contributes to the inflammatory state or is augmented by it. To optimize islet transplantation for diabetes reversal, we suggest that targeting these interacting barriers and the accompanying inflammation may represent an improved approach to achieve successful clinical islet transplantation by enhancing islet survival, regeneration or neogenesis potential, and tolerance induction. Overall, we consider the proinflammatory effects of important technical, immunological, and metabolic barriers including: 1) islet isolation and transplantation, including selection of implantation site; 2) recurrent autoimmunity, alloimmune rejection, and unique features of the autoimmune-prone immune system; and 3) the deranged metabolism of the islet transplant recipient. Consideration of these themes reveals that each is interrelated to and exacerbated by the other and that this connection is mediated by a systemic inflammatory state. This inflammatory state may form the central barrier to successful islet transplantation. Overall, there remains substantial promise in islet transplantation with several avenues of ongoing promising research. This review focuses on interactions between the technical, immunological, and metabolic barriers that must be overcome to optimize the success of this important therapeutic approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.