ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose tissue.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Reduced flow-and acetylcholine-induced dilations in visceral compared to subcutaneous adipose arterioles in human morbid obesity.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- In vitro and in vivo effects of metformin on human adipose tissue adiponectin.Obesity facts · 2011Trial
- Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome.Adipocyte · 2025Article
- Metabolic effects of lipectomy and of adipose tissue transplantation.Obesity (Silver Spring, Md.) · 2023Review
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles.Archives of medical science : AMS · 2021Article
- Reference Gene Optimization for Circadian Gene Expression Analysis in Human Adipose Tissue.Journal of biological rhythms · 2020Article
- Glitazone loaded fat enhances adiponectin production and inhibits breast cancer cell proliferation.Molecular biology reports · 2019Article
- Adipokines secretion in feline primary adipose tissue culture in response to dietary fatty acids.BMC veterinary research · 2019Article
- A Comparative Peptidomic Characterization of Cultured Skeletal Muscle Tissues Derived FromFrontiers in endocrinology · 2019Article
- Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome.Clinical epigenetics · 2018Article
- Autologous fat transplants to deliver glitazone and adiponectin for vasculoprotection.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice.Obesity (Silver Spring, Md.) · 2016Article
- Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.Nature chemical biology · 2016Article
- Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.Frontiers in nutrition · 2016Review
- Assembly of adiponectin oligomers.Reviews in endocrine & metabolic disorders · 2014Review
- Synergistic anti-inflammatory effect: simvastatin and pioglitazone reduce inflammatory markers of plasma and epicardial adipose tissue of coronary patients with metabolic syndrome.Diabetology & metabolic syndrome · 2014Article
- Adiponectin, chemerin, cytokines, and dipeptidyl peptidase 4 are released from human adipose tissue in a depot-dependent manner: an in vitro system including human serum albumin.BMC endocrine disorders · 2014Article
- New insight into adiponectin role in obesity and obesity-related diseases.BioMed research international · 2014Review
- Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity.Adipocyte · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The subcutaneous (S) and visceral (V) adipose tissue (AT) depots are increasingly recognized as distinct. To test the hypothesis that depot differences exist for adiponectin, fresh and cultured human VAT and SAT from obese type 2 diabetic (T2D) and obese nondiabetic (ND) subjects was examined to determine whether differences in adiponectin content and secretion occurred as a function of depot studied, diabetic status, and response to thiazolidinedione treatment. VAT and SAT were obtained by biopsy and AT explants cultured in defined media for 7 days. Protein expression was assessed by Western blot. Adiponectin content of conditioned medium was determined by radioimmunoassay. Diabetic status had no effect on adiponectin secretion over days 0-2 of culture. In ND SAT, secretion fell over days 2-4 but was sustained at greater levels vs. T2D SAT. In both ND and T2D VAT, adiponectin secretion was low, similar to T2D SAT. Over the 7-day culture period, cellular adiponectin increased in ND SAT and VAT; it remained unchanged in T2D SAT and VAT. Pioglitazone increased adiponectin secretion and content in all SAT. Pioglitazone failed to increase adiponectin secretion from either ND or T2D VAT and increased cellular content only in ND VAT. AT depot differences exist in the secretion of adiponectin and responsiveness to thiazolidinedione treatment. These data suggest that SAT, not VAT, appears to be the major contributor to increased circulating adiponectin levels in response to pioglitazone treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.