ArticleProceedings of the National Academy of Sciences of the United States of America2008
Organ renewal and cell divisions by differentiated cells in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.The Journal of cell biology · 2026Article
- A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.Nature communications · 2024Article
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- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
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- Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells.Journal of molecular cell biology · 2020Article
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- Development and Function of theGenetics · 2018Review
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- Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea.PLoS genetics · 2016Article
- Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae.PloS one · 2016Article
- Multipotent versus differentiated cell fate selection in the developing Drosophila airways.eLife · 2015Article
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- Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein.Science (New York, N.Y.) · 2014Article
- Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches.Science (New York, N.Y.) · 2014Article
- Receptor tyrosine kinases in Drosophila development.Cold Spring Harbor perspectives in biology · 2013Review
- The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling.Science signaling · 2013Article
- Branching morphogenesis: from cells to organs and back.Cold Spring Harbor perspectives in biology · 2012Review
- Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis.Development (Cambridge, England) · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
For many organs, the processes of renewal and regeneration recruit stem cells to replace differentiated, postmitotic cells, but the capacity of an organ's differentiated cells to divide and contribute is uncertain. Most cells of the Drosophila adult are the descendants of dedicated precursors that divide and replace larval cells that are histolyzed during metamorphosis. We investigated the provenance of cells that reconstitute the second thoracic metamere of the tracheal system (Tr2). These cells contribute the precursors for Branchless(FGF)-dependent growth of the dorsal air sacs, the major tracheal organs of the adult fly. We found that, in contrast to the cells in other tracheal metameres that proceed through many cycles of endoreplication, the cells that constitute the Tr2 branches in young larvae do not. Like the cells in other tracheal metameres, these cells arrest mitotic cycling in the embryo and form differentiated, air-filled tracheal branches of the larva. We report here that they reinitiate cell divisions during the third instar (L3) to increase the Tr2 population by approximately 10-fold with multipotent cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.