SynthesisInternational journal of epidemiology2008
Systematic review of orogenital HIV-1 transmission probabilities.
Synthesis in International journal of epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Estimating per-act HIV transmission risk: a systematic review.AIDS (London, England) · 2014Pooled it
- Heterosexual HIV-1 infectiousness and antiretroviral use: systematic review of prospective studies of discordant couples.Epidemiology (Cambridge, Mass.) · 2013Pooled it
- Concurrent sexual partnerships do not explain the HIV epidemics in Africa: a systematic review of the evidence.Journal of the International AIDS Society · 2010Pooled it
- HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention.International journal of epidemiology · 2010Pooled it
- Determinants of Intention to Use HIV Pre-exposure Prophylaxis and Condom Use Among a Sample of Cisgender Female Sex Workers Working Mostly Outdoors in Madrid, Spain.Archives of sexual behavior · 2024Article
- A mixed methods investigation of the relationship between blood donor policy, interest in donation, and willingness to donate among gay, bisexual, and other men who have sex with men in Ontario, Canada.BMC public health · 2022Article
- Expert consensus statement on the science of HIV in the context of criminal law.Journal of the International AIDS Society · 2018Article
- HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation.Frontiers in immunology · 2017Review
- The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Antiviral factors and type I/III interferon expression associated with regulatory factors in the oral epithelial cells from HIV-1-serodiscordant couples.Scientific reports · 2016Article
- HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.AIDS (London, England) · 2014Article
- Canadian consensus statement on HIV and its transmission in the context of criminal law.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2014Article
- Article
- A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa.PloS one · 2014Article
- Reconceptualizing the HIV epidemiology and prevention needs of Female Sex Workers (FSW) in Swaziland.PloS one · 2014Article
- BRIEF - SYNOPSIS OF THE CURRENT EVIDENCE ON THE RISK OF HIV TRANSMISSION.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2013Article
- Charges for criminal exposure to HIV and aggravated prostitution filed in the Nashville, Tennessee Prosecutorial Region 2000-2010.AIDS and behavior · 2013Article
- Criminalization of HIV transmission and exposure: research and policy agenda.American journal of public health · 2013Article
- Heterosexual anal intercourse: a neglected risk factor for HIV?American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Review
- Impact of mucosal inflammation on oral simian immunodeficiency virus transmission.Journal of virology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundThe objective was to assess the risk of HIV transmission from orogenital intercourse (OI).
methodsSystematic review of the literature on HIV-1 infectiousness through OI conducted according to MOOSE guidelines for reviews of observational studies. The PubMed database and bibliographies of relevant articles were searched to July 2007.
resultsOf the titles, 56 214 were searched from which 10 potentially appropriate studies were identified; two additional studies were identified through bibliographies and one through discussion with experts. There were 10 included studies, providing estimates of transmission probabilities per-partner (n = 5), incidence per-partner (n = 3), per-study participant (n = 3, following initially seronegative individuals whose partners are of unknown serostatus) and per-act (n = 3). Only four of 10 studies reported non-zero estimates: two per-partner estimates (20%, 95% CI: 6-51, n = 10 and a model-based estimate, 1%, range 0.85-2.3%), one per-study participant estimate (0.37%, 95% CI: 0.10-1.34%) and one per-act estimate (0.04%, 95% CI: 0.01-0.17%). Upper bounds for the 95% CI for zero estimates tended to be relatively large due to the small study sample sizes: 9.0, 12.1 and 2.8% for per-partner; 4.7, 9.6 and 1.8 per 100 person-years for incidence per-partner; 4.4% per-study participant and 0.45 and 0.02% for per-act. Given the small number of studies, a meta-analysis was not considered appropriate.
conclusionsThere are currently insufficient data to estimate precisely the risk from OI exposure. The low risk of transmission evident from identified studies means that more and larger studies would be required to provide sufficient evidence to derive more precise estimates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.